Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
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DOI：
10.1016/j.immuni.2014.05.002
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发表时间：
2014-06-19
期刊：
影响因子：
32.4
通讯作者：
Irazoqui, Javier E.
中科院分区：
文献类型：
--
作者：
Visvikis, Orane;Ihuegbu, Nnamdi;Labed, Sid A.;Luhachack, Lyly G.;Alves, Anna-Maria F.;Wollenberg, Amanda C.;Stuart, Lynda M.;Stormo, Gary D.;Irazoqui, Javier E.
动物宿主对感染的防御需要防御基因在正确的地方和正确的时间表达。要理解这种对宿主防御的严密控制，需要阐明所涉及的转录因子。在秀丽隐杆线虫模型中使用无偏方法，我们发现HLH-30（在哺乳动物中称为TFEB）是宿主防御的关键转录因子。HLH-30在金黄色葡萄球菌感染后不久被激活，并驱动近80%的宿主反应的表达，包括对宿主感染耐受性至关重要的抗菌和自噬基因。TFEB在小鼠巨噬细胞中也被S.金黄色葡萄球菌感染，并需要适当的转录诱导几个促炎细胞因子和趋化因子。因此，我们的数据表明，TFEB是一个以前不受重视的，进化上古老的转录因子在宿主对感染的反应。
Animal host defense against infection requires the expression of defense genes at the right place and the right time. To understand such tight control of host defense requires the elucidation of the transcription factors involved. Using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense. HLH-30 was activated shortly after Staphylococcus aureus infection, and drove the expression of close to 80% of the host response, including antimicrobial and autophagy genes that were essential for host tolerance of infection. TFEB was also rapidly activated in murine macrophages upon S. aureus infection, and was required for proper transcriptional induction of several proinflammatory cytokines and chemokines. Thus, our data suggest that TFEB is a previously unappreciated, evolutionarily ancient transcription factor in the host response to infection.
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影响因子：
3.7
作者：
Engelmann I;Griffon A;Tichit L;Montañana-Sanchis F;Wang G;Reinke V;Waterston RH;Hillier LW;Ewbank JJ
通讯作者：
Ewbank JJ
DOI：
10.1126/science.1179050
发表时间：
2009-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amit I;Garber M;Chevrier N;Leite AP;Donner Y;Eisenhaure T;Guttman M;Grenier JK;Li W;Zuk O;Schubert LA;Birditt B;Shay T;Goren A;Zhang X;Smith Z;Deering R;McDonald RC;Cabili M;Bernstein BE;Rinn JL;Meissner A;Root DE;Hacohen N;Regev A
通讯作者：
Regev A
影响因子：
16
作者：
Kroemer G;Mariño G;Levine B
通讯作者：
Levine B
影响因子：
100.3
作者：
Amit, Ido;Regev, Aviv;Hacohen, Nir
通讯作者：
Hacohen, Nir
影响因子：
--
作者：
Ganesan, Sandhya;Aggarwal, Kamna;Paquette, Nicholas;Silverman, Neal
通讯作者：
Silverman, Neal