Socioemotional mechanisms of loneliness in subclinical psychosis.
Socioemotional mechanisms of loneliness in subclinical psychosis.
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DOI：
10.1016/j.schres.2021.10.002
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发表时间：
2021-12
影响因子：
4.5
通讯作者：
Karlsgodt KH
中科院分区：
文献类型：
--
作者：
Leathem LD;Currin DL;Montoya AK;Karlsgodt KH
孤独症是一般人群和精神病谱个体（包括经历亚临床精神病样经历（PLEs）的个体）身心健康的重要预测因素。然而，精神病谱系中孤独的潜在机制还没有很好地理解。情绪处理缺陷在精神病谱系中得到了很好的描述，社会情绪处理偏见通过改变社会评价（包括拒绝判断）对孤独的发展和维持至关重要。因此，我们认为，PLEs与孤独感增加有关，这种关系是由社会情绪处理的改变介导的。我们还探讨了这一途径如何受到情绪和焦虑症状的影响，这些症状与精神病谱系中的孤独感有关。作为人类连接组项目的一部分，一般健康的成年人（n = 1180）报告了神经病学和社会功能，并完成了宾夕法尼亚州情绪识别任务，以评估识别情绪的效率。我们发现，较高的报告的PLEs与孤独和感知拒绝水平升高相关，这些因素通过多个独立的途径联系在一起。第一，焦虑/抑郁和情绪处理效率独立中介的PLE孤独关系。其次，我们发现，PLEs和孤独之间的关联是通过低效的情绪识别，然后是更高水平的感知拒绝介导的。亚临床精神病孤独感增加的这些可分离的机制对精神病谱系中社会功能的治疗和继续研究具有意义。
Loneliness is an important predictor of physical and mental health in the general population and in individuals across the psychosis spectrum, including those experiencing subclinical psychotic-like experiences (PLEs). However, the mechanisms underlying loneliness in the psychosis spectrum are not well understood. Emotion processing deficits are well described across the psychosis spectrum, and socioemotional processing biases are critical for the development and maintenance of loneliness through altered social appraisal, including judgements of rejection. Therefore, we propose that PLEs are associated with increased loneliness, and the relationship is mediated by alterations in socioemotional processing. We also explored how this pathway may be affected by mood and anxiety symptoms, which have been associated with loneliness across the psychosis spectrum. As part of the Human Connectome Project, generally healthy adults (n = 1180) reported symptomatology and social functioning and completed the Penn Emotion Recognition Task to assess efficiency in identifying emotions. We found that higher reported PLEs were associated with elevated levels of loneliness and perceived rejection and that these factors were linked by multiple independent pathways. First, anxiety/depression and emotion processing efficiency independently mediated the PLE-loneliness relationship. Second, we found that the association between PLEs and loneliness was serially mediated through inefficient emotion recognition then higher levels of perceived rejection. These separable mechanisms of increased loneliness in subclinical psychosis have implications for treatment and continued study of social functioning in the psychosis spectrum.
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影响因子：
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