Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines
Two regions of the mouse mammary tumor virus long terminal repeat regulate the activity of its promoter in mammary cell lines
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小鼠乳腺肿瘤病毒长末端重复序列的两个区域调节其启动子在乳腺细胞系中的活性
DOI：
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发表时间：
1991
影响因子：
5.3
通讯作者：
G. Hager
中科院分区：
文献类型：
--
作者：
P. Lefebvre;D. Berard;M. Cordingley;and;G. Hager
In vivo expression of the mouse mammary tumor virus (MMTV) is restricted to a few organs, with the highest rate of transcription found in the mammary gland. Using a series of mammary and nonmammary murine cell lines, we have identified two regulatory elements, located upstream of the hormone responsive element, that specifically regulate the MMTV promoter. The first element displays an enhancerlike activity and is coincident with the binding of a nuclear factor (designated MP4; position -1078 to -1052 in the long terminal repeat) whose presence is apparently restricted to mammary cell lines. The second regulatory region mediates a repressive activity and is mapped to the long terminal repeat segment from -415 to -483. This repression is specific for a particular subtype of mammary cells (RAC cells) able to grow under two differentiation states (A. Sonnenberg, H. Daams, J. Calafat, and J. Hilgers, Cancer Res. 46:5913-5922, 1986). The MMTV promoter in mammary cell lines thus appears to be modulated by two cis-acting elements that are likely to be involved in tissue-specific expression in vivo.
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转基因小鼠中糖皮质激素对小鼠乳腺肿瘤病毒序列的调节。
DOI：
10.1073/pnas.82.17.5880
发表时间：
1985
影响因子：
11.1
作者：
Ross,SR;Solter,D
通讯作者：
Solter,D
影响因子：
14.9
作者：
Kimberlin L. Morley;Mark G. Toohey;D. O. Peterson
通讯作者：
Kimberlin L. Morley;Mark G. Toohey;D. O. Peterson
DOI：
--
发表时间：
1989-07
期刊：
The American journal of pathology
影响因子：
--
作者：
Paul K. Pattengale;Timothy A. Stewart;Aya Leder;E. Sinn;William J. Muller;I. Tepler;Emmett V. Schmidt;Philip Leder
通讯作者：
Paul K. Pattengale;Timothy A. Stewart;Aya Leder;E. Sinn;William J. Muller;I. Tepler;Emmett V. Schmidt;Philip Leder
影响因子：
2.7
作者：
S. Nordeen
通讯作者：
S. Nordeen
小鼠乳腺肿瘤病毒 DNA 甲基化：组织特异性变异。
影响因子：
3.7
作者：
Breznik,T;Traina-Dorge,V;Gama-Sosa,M;Gehrke,CW;Ehrlich,M;Medina,D;Butel,JS;Cohen,JC
通讯作者：
Cohen,JC