Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator.
Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator.
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DOI：
10.1093/gbe/evx220
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发表时间：
2017-11-01
影响因子：
3.3
通讯作者：
Brown MJF
中科院分区：
文献类型：
--
作者：
Manfredini F;Romero AE;Pedroso I;Paccanaro A;Sumner S;Brown MJF
生活史的转变需要在行为和生理层面上进行重大的重新编程。交配和生殖成熟在广泛的生物体中都会触发生殖组织中基因转录的变化，但我们对交配或生殖成熟失败的分子后果知之甚少，也不清楚这些过程在多大程度上触发神经和生理变化。在这项研究中，我们研究了支持行为变化的分子过程，这些变化伴随着关键的传粉者熊蜂的主要生活史转变。我们比较了成功或失败地从处女和未成熟状态切换到交配和生殖成熟状态的蜂王的神经转录。成功和失败都与不同的分子图谱有关，说明了成年期的发育如何在单一种姓的优生优育昆虫中触发不同的分子图谱。交配和生殖成熟的失败可以用大脑基因转录的普遍上调来解释。在基因共表达网络分析中，我们确定了21个高度关联的基因：9个基因参与神经过程，4个基因调控基因表达。这表明，协商生活史的转变涉及到重大的神经处理和重新编程，而不仅仅是生理上的变化。这些发现为昆虫的基本生活史转变提供了新的见解。交配或生殖成熟失败是自然系统变异的一个被忽视的组成部分，尽管它在许多有性繁殖生物体中普遍存在，值得在未来进行更深入的研究。
Life-history transitions require major reprogramming at the behavioral and physiological level. Mating and reproductive maturation are known to trigger changes in gene transcription in reproductive tissues in a wide range of organisms, but we understand little about the molecular consequences of a failure to mate or become reproductively mature, and it is not clear to what extent these processes trigger neural as well as physiological changes. In this study, we examined the molecular processes underpinning the behavioral changes that accompany the major life-history transitions in a key pollinator, the bumblebee Bombus terrestris. We compared neuro-transcription in queens that succeeded or failed in switching from virgin and immature states, to mated and reproductively mature states. Both successes and failures were associated with distinct molecular profiles, illustrating how development during adulthood triggers distinct molecular profiles within a single caste of a eusocial insect. Failures in both mating and reproductive maturation were explained by a general up-regulation of brain gene transcription. We identified 21 genes that were highly connected in a gene coexpression network analysis: nine genes are involved in neural processes and four are regulators of gene expression. This suggests that negotiating life-history transitions involves significant neural processing and reprogramming, and not just changes in physiology. These findings provide novel insights into basic life-history transitions of an insect. Failure to mate or to become reproductively mature is an overlooked component of variation in natural systems, despite its prevalence in many sexually reproducing organisms, and deserves deeper investigation in the future.
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影响因子：
14.9
作者：
Hu Z;Chang YC;Wang Y;Huang CL;Liu Y;Tian F;Granger B;Delisi C
通讯作者：
Delisi C
影响因子：
3.7
作者：
Biswas S;Reinhard J;Oakeshott J;Russell R;Srinivasan MV;Claudianos C
通讯作者：
Claudianos C
影响因子：
3.7
作者：
Gomulski LM;Dimopoulos G;Xi Z;Scolari F;Gabrieli P;Siciliano P;Clarke AR;Malacrida AR;Gasperi G
通讯作者：
Gasperi G
影响因子：
12.3
作者：
Barribeau SM;Sadd BM;du Plessis L;Brown MJ;Buechel SD;Cappelle K;Carolan JC;Christiaens O;Colgan TJ;Erler S;Evans J;Helbing S;Karaus E;Lattorff HM;Marxer M;Meeus I;Näpflin K;Niu J;Schmid-Hempel R;Smagghe G;Waterhouse RM;Yu N;Zdobnov EM;Schmid-Hempel P
通讯作者：
Schmid-Hempel P
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y