Prelimbic and infralimbic neurons signal distinct aspects of appetitive instrumental behavior.
Prelimbic and infralimbic neurons signal distinct aspects of appetitive instrumental behavior.
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DOI：
10.1371/journal.pone.0057575
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Quirk GJ
中科院分区：
文献类型：
--
作者：
Burgos-Robles A;Bravo-Rivera H;Quirk GJ
人们认为内侧前额叶皮层（mPFC）的离散子区域调节食欲行为的不同方面，然而，这一假设缺乏生理学支持。在本研究中，我们使用多通道单单位记录比较的反应，在边缘前（PL）和边缘下（IL）的mPFC子区域的神经元，在大鼠按下杠杆，以获得蔗糖丸的强化（VI-60）的可变间隔时间表。两个结构中大约25%的神经元在奖励（但不是无奖励）的杠杆按压过程中表现出明显的兴奋性反应。然而，PL和IL的奖励反应的时间过程是显着不同的。大多数PL神经元表现出快速和短暂的反应，在交付的蔗糖颗粒，而大多数IL神经元表现出延迟和延长的反应与收集赚取的蔗糖颗粒。我们进一步研究了局部药理学失活的IL和PL中奖励反应的功能意义。IL失活显着延迟收集赚取蔗糖颗粒，而PL失活产生没有明显的影响。这些发现支持了这一假设，PL和IL信号的食欲行为的不同方面，并建议IL信号促进奖励收集。
It is thought that discrete subregions of the medial prefrontal cortex (mPFC) regulate different aspects of appetitive behavior, however, physiological support for this hypothesis has been lacking. In the present study, we used multichannel single-unit recording to compare the response of neurons in the prelimbic (PL) and infralimbic (IL) subregions of the mPFC, in rats pressing a lever to obtain sucrose pellets on a variable interval schedule of reinforcement (VI-60). Approximately 25% of neurons in both structures exhibited prominent excitatory responses during rewarded, but not unrewarded, lever presses. The time courses of reward responses in PL and IL, however, were markedly different. Most PL neurons exhibited fast and transient responses at the delivery of sucrose pellets, whereas most IL neurons exhibited delayed and prolonged responses associated with the collection of earned sucrose pellets. We further examined the functional significance of reward responses in IL and PL with local pharmacological inactivation. IL inactivation significantly delayed the collection of earned sucrose pellets, whereas PL inactivation produced no discernible effects. These findings support the hypothesis that PL and IL signal distinct aspects of appetitive behavior, and suggest that IL signaling facilitates reward collection.
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DOI：
10.1523/jneurosci.4904-07.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hefner K;Whittle N;Juhasz J;Norcross M;Karlsson RM;Saksida LM;Bussey TJ;Singewald N;Holmes A
通讯作者：
Holmes A
影响因子：
2.9
作者：
Petrovich, Gorica D.;Gallagher, Michela
通讯作者：
Gallagher, Michela
影响因子：
2.7
作者：
Pratt, WE;Mizumori, SJY
通讯作者：
Mizumori, SJY
影响因子：
2
作者：
Knapska, Ewelina;Maren, Stephen
通讯作者：
Maren, Stephen
影响因子：
3.3
作者：
Ishikawa, A.;Ambroggi, F.;Fields, H. L.
通讯作者：
Fields, H. L.