Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes.
Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes.
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DOI：
10.1016/j.yfrne.2013.10.004
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发表时间：
2014-01
影响因子：
7.4
通讯作者：
Blaustein, Jeffrey D.
中科院分区：
文献类型：
--
作者：
Holder, Mary K.;Blaustein, Jeffrey D.
关键词：
青春期和青春期是人生的重大转变，在此期间，个体的生理和行为从青少年向成人转变。在这里，我们回顾了记录青春期和青少年发育期间压力源对成人大脑和行为影响的研究。青春期/青春期经历的复杂或复合压力源通常会增加压力反应性，增加焦虑和抑郁，并降低成年后的认知能力。这些行为变化与海马体积减少和神经可塑性改变相关。此外，青春期的压力经历会扰乱性行为、认知和情绪方面对性腺激素的行为反应。这些行为变化与某些雌激素集中大脑区域中雌激素受体密度的改变相关，这表明大脑对激素的反应发生了重塑。提出了一种假设，即免疫系统的激活会导致慢性神经炎症，从而可能介导成年期激素调节行为的改变。
Puberty and adolescence are major life transitions during which an individual’s physiology and behavior changes from that of a juvenile to that of an adult. Here we review studies documenting the effects of stressors during pubertal and adolescent development on the adult brain and behavior. The experience of complex or compound stressors during puberty/adolescence generally increases stress reactivity, increases anxiety and depression, and decreases cognitive performance in adulthood. These behavioral changes correlate with decreased hippocampal volumes and alterations in neural plasticity. Moreover, stressful experiences during puberty disrupt behavioral responses to gonadal hormones both in sexual performance and on cognition and emotionality. These behavioral changes correlate with altered estrogen receptor densities in some estrogen-concentrating brain areas, suggesting a remodeling of the brain’s response to hormones. A hypothesis is presented that activation of the immune system results in chronic neuroinflammation that may mediate the alterations of hormone-modulated behaviors in adulthood.
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影响因子：
7.6
作者：
Andersen, SL;Teicher, MH
通讯作者：
Teicher, MH
影响因子：
3.4
作者：
Bekman, Nicole M.;Cummins, Kevin;Brown, Sandra A.
通讯作者：
Brown, Sandra A.
影响因子：
2.9
作者：
BERNARDI, M;VERGONI, AV;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
3
作者：
Bilbo SD;Schwarz JM
通讯作者：
Schwarz JM
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL