Occupation and bladder cancer in a population-based case-control study in Northern New England.
Occupation and bladder cancer in a population-based case-control study in Northern New England.
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DOI：
10.1136/oem.2009.052571
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发表时间：
2011-04
影响因子：
4.9
通讯作者：
Silverman DT
中科院分区：
文献类型：
--
作者：
Colt JS;Karagas MR;Schwenn M;Baris D;Johnson A;Stewart P;Verrill C;Moore LE;Lubin J;Ward MH;Samanic C;Rothman N;Cantor KP;Beane Freeman LE;Schned A;Cherala S;Silverman DT
我们使用了来自新英格兰一项大型的、基于人群的病例对照研究的数据，以检查职业、行业和膀胱癌风险之间的关系。终身职业史是通过个人访谈获得的，来自2001年至2004年缅因州、新罕布什尔州和佛蒙特州居民中新诊断为膀胱尿路上皮癌的1,158例患者，以及从机动车部门记录（年龄30至64岁）或医疗保险受益人记录（65至79岁）中选择的1,402例人群对照。非条件logistic回归用于计算比值比（OR）和95%置信区间（CI），调整人口统计学因素，吸烟和高风险职业的就业，而不是被分析的。男性精密金属工人和金属加工/塑料加工机器操作员的风险显著升高，并随着工作时间的延长，风险有显著趋势（精密金属工人：OR=2.2; CI：1.4，3.4，Ptrend =0.0065;金属加工/塑料加工机器操作员：OR=1.6; CI：1.01，2.6，Ptrend=0.047）。风险随着就业时间的延长而显著增加的其他职业/行业包括：对男子而言，纺织机械操作员、机械师/修理工、汽车机械师、水管工、计算机系统分析员、信息员以及园林和园艺服务行业工人;对妇女来说，服务性职业、保健服务、清洁和建筑服务、与管理有关的职业、电子元件和配件制造、运输设备制造业。报告使用金属加工液（MWF）的男性膀胱癌风险显著升高（OR=1.7; 95%CI：1.1，2.5），我们对金属工人和MWF暴露的研究结果支持MWF某些成分可能对人类膀胱致癌的假设。我们的研究结果也证实了许多其他先前报道的膀胱癌风险和各种职业之间的关联。使用本研究中管理的特定工作问卷中收集的信息进行更详细的分析，可能有助于确定MWF中可能致癌的成分，以及人们在各种职业中暴露的其他膀胱致癌物。
We used data from a large, population-based case-control study in New England to examine relationships between occupation, industry, and bladder cancer risk. Lifetime occupational histories were obtained by personal interview from 1,158 patients newly diagnosed with urothelial carcinoma of the bladder between 2001 and 2004 among residents of Maine, New Hampshire, and Vermont, and from 1,402 population controls selected from Department of Motor Vehicle records (ages 30 to 64 years) or Medicare beneficiary records (65 to 79 years). Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for demographic factors, smoking, and employment in high-risk occupations other than the one being analyzed. Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR=2.2; CI: 1.4, 3.4, Ptrend =0.0065; metalworking/plasticworking machine operators: OR=1.6; CI: 1.01, 2.6, Ptrend=0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape and horticultural services industry workers; and for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components and accessories manufacturing, and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR=1.7; 95% CI: 1.1, 2.5), Our findings for metalworkers and for MWF exposure support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder in humans. Our results also corroborate many other previously-reported associations between bladder cancer risk and various occupations. More detailed analyses using information collected in job-specific questionnaires administered in this study may help to identify components of MWF that may be carcinogenic, and other bladder carcinogens to which people are exposed in a variety of occupations.
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影响因子：
6.4
作者：
BONASSI, S;MERLO, F;PUNTONI, R
通讯作者：
PUNTONI, R
DOI：
10.1097/01.jom.0000169094.77036.1d
发表时间：
2005-08-01
影响因子：
3.2
作者：
Band, PR;Le, ND;Gallagher, RP
通讯作者：
Gallagher, RP
影响因子：
7.7
作者：
GONZALEZ, CA;LOPEZABENTE, G;NEBOT, M
通讯作者：
NEBOT, M
影响因子：
6.3
作者：
HANSEN, ES
通讯作者：
HANSEN, ES
影响因子：
12.7
作者：
BROWNSON, RC;CHANG, JC;DAVIS, JR
通讯作者：
DAVIS, JR