Persistence of viral infection despite similar killing efficacy of antiviral CD8(+) T cells during acute and chronic phases of infection.
Persistence of viral infection despite similar killing efficacy of antiviral CD8(+) T cells during acute and chronic phases of infection.
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DOI：
10.1016/j.virol.2010.05.029
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发表时间：
2010-09-15
期刊：
影响因子：
3.7
通讯作者：
Byers AM
中科院分区：
文献类型：
--
作者：
Ganusov VV;Lukacher AE;Byers AM
为什么有些病毒会造成慢性感染，而另一些则不会，人们对此知之甚少。一种可能是宿主的免疫反应在慢性感染期间受损，无法从宿主中清除病毒。在这份报告中，我们使用最近提出的框架来估计CD 8 + T细胞的人均杀伤效率，特异性多瘤病毒（PyV），它在小鼠中建立了慢性感染。令人惊讶的是，在感染的急性期期间PyV特异性效应CD 8 + T细胞的估计的每细胞杀伤功效与对淋巴细胞性脉络丛脑膜炎病毒（LCMV-Armstrong）特异性的效应CD 8 + T细胞的功效非常相似，所述淋巴细胞性脉络丛脑膜炎病毒从宿主中清除。我们的研究结果表明，PyV的持久性并不产生一个低效的PyV特异性CD 8 + T细胞反应，和其他宿主或病毒因素是负责PyV建立慢性感染的能力。
Why some viruses establish chronic infections while others do not is poorly understood. One possibility is that the host's immune response is impaired during chronic infections and is unable to clear the virus from the host. In this report, we use a recently proposed framework to estimate the per capita killing efficacy of CD8+ T cells, specific for the polyoma virus (PyV), which establishes a chronic infection in mice. Surprisingly, the estimated per cell killing efficacy of PyV-specific effector CD8+ T cells during the acute phase of the infection was very similar to the efficacy of effector CD8+ T cells specific to lymphocytic choriomeningitis virus (LCMV-Armstrong), which is cleared from the host. Our results suggest that persistence of PyV does not result from the generation of an inefficient PyV-specific CD8+ T cell response, and that other host or viral factors are responsible for the ability of PyV to establish chronic infection.
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DOI：
10.1084/jem.20001021
发表时间：
2002-03-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blattman JN;Antia R;Sourdive DJ;Wang X;Kaech SM;Murali-Krishna K;Altman JD;Ahmed R
通讯作者：
Ahmed R
DOI：
10.1073/pnas.89.21.10365
发表时间：
1992-11-01
影响因子：
11.1
作者：
GROSSMAN, Z;PAUL, WE
通讯作者：
PAUL, WE
影响因子：
30.5
作者：
Badovinac, VP;Porter, BB;Harty, JT
通讯作者：
Harty, JT
影响因子：
30.5
作者：
Kaech, SM;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
Barber, DL;Wherry, EJ;Ahmed, R
通讯作者：
Ahmed, R