Circular RNAs: biogenesis, expression and their potential roles in reproduction.
Circular RNAs: biogenesis, expression and their potential roles in reproduction.
复制标题
圆形RNA：生物发生，表达及其在繁殖中的潜在作用。
DOI：
10.1186/s13048-018-0381-4
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发表时间：
2018-01-17
影响因子：
4
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Quan G;Li J
与其他非编码RNA（ncRNA）不同，环状RNA（circRNA）通常以共价连接的环形式存在，缺乏5′帽和3′尾。circRNA被认为是异常RNA剪接事件的剪接中间体、副产物或产物。然而，高通量测序技术与生物信息学相结合，最近发现了许多不同物种细胞中的数千种内源性circRNA。这些circRNA表现出丰富的表达、进化保守性、细胞或组织特异性表达以及对核酸外切酶或核糖核酸酶（RNase）引起的降解具有较高的抗性等特征，表明它们具有潜在的生物学意义。然而，这些circRNA的功能，它们的作用机制，以及它们的生物发生和降解的调节在很大程度上仍然不清楚。本文将综述circRNA在生殖过程中的研究进展。此外，还将讨论circRNA在该领域的前景。
Unlike other non-coding RNAs (ncRNAs), circular RNA (circRNA) is generally presented as a covalently linked circle lacking both a 5′ cap and a 3′ tail. circRNAs were thought to be spliced intermediates, byproducts, or products of abnormal RNA splicing events. However, the high-throughput sequencing technology coupled with bioinformatics has recently uncovered thousands of endogenous circRNAs in cells of many different species. These circRNAs show various features, such as abundant expression, evolutionary conservation, cell- or tissue-specific expression, and a higher resistance to degradation caused by exonuclease or ribonuclease (RNase), suggesting their potentially biological significance. However, the function of these circRNAs, their mechanism of action, and the regulation of their biogenesis and degradation remains largely unclear. The current research and findings of circRNA in the context of reproduction will be reviewed. Additionally, the perspectives of circRNAs in the field will be discussed.
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