Pubertal immune challenge blocks the ability of estradiol to enhance performance on cognitive tasks in adult female mice.
Pubertal immune challenge blocks the ability of estradiol to enhance performance on cognitive tasks in adult female mice.
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DOI：
10.1016/j.psyneuen.2012.11.003
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发表时间：
2013-07
影响因子：
3.7
通讯作者：
Blaustein, Jeffrey D.
中科院分区：
文献类型：
--
作者：
Ismail, Nafissa;Blaustein, Jeffrey D.
青春期是一个以大脑重组为特征的时期，这有助于神经和行为对性腺类固醇的反应的发展。在此之前，我们已经证明，在发育期（约6周龄）小鼠单次注射细菌内毒素脂多糖（LPS; 1.5mg/kg IP）会降低成年期雌二醇和黄体酮对小鼠的性接受性。这些发现表明，青春期免疫挑战有一个持久的影响，降低性腺类固醇激素的行为反应。由于雌二醇可以改善小鼠在某些任务中的认知功能，我们研究了青春期免疫刺激对雌二醇增强认知功能的影响。我们假设雌二醇在提高雌性小鼠在青春期接受LPS治疗的特定认知任务中的表现方面效果较差。6周龄（青春期）和10周龄（成年）雌性CD1小鼠分别注射生理盐水或LPS。五周后，他们切除卵巢，皮下植入雌二醇或充油硅胶©胶囊，一周后进行认知功能测试。在社会歧视和识别测试中，青少年调查的持续时间作为社会记忆的测量，在物体识别和放置测试中，物体调查的持续时间作为物体记忆的测量。慢性雌二醇治疗增强了女性在成年期的社会和物体记忆。相比之下，在6周大时接受LPS治疗的雌性小鼠中，雌二醇未能改善社交和物体记忆。这些结果支持了一个假设，即在青春期受到免疫挑战至少会降低雌二醇的一些认知作用。此外，这些结果支持这样一种观点，即青春期免疫挑战损害了卵巢激素对各种行为的影响。
Puberty is a period characterized by brain reorganization that contributes to the development of neural and behavioral responses to gonadal steroids. Previously, we have shown that a single injection of the bacterial endotoxin, lipopolysaccharide (LPS; 1.5mg/kg IP), during the pubertal period (around 6 weeks old) in mice decreases sexual receptivity in response to estradiol and progesterone in adulthood. These findings suggest that pubertal immune challenge has an enduring effect of decreasing the behavioral responsiveness to gonadal steroid hormones. Since estradiol improves cognitive function in certain tasks in mice, we investigated the effect of pubertal immune challenge on the ability of estradiol to enhance cognitive function. We hypothesized that estradiol would be less effective at enhancing performance on particular cognitive tasks in female mice treated with LPS during puberty. Six-week old (pubertal) and ten-week old (adult) female CD1 mice were injected with either saline or LPS. Five weeks later, they were ovariectomized and implanted subcutaneously with either an estradiol- or oil-filled Silastic© capsule followed one week later with testing for cognitive function. The duration of juvenile investigation during social discrimination and recognition tests was used as a measure of social memory, and the duration of object investigation during object recognition and placement tests was used as a measure of object memory. Chronic estradiol treatment enhanced social and object memory in saline-treated females and in females treated with LPS in adulthood. In contrast, in females treated with LPS at 6 weeks old, estradiol failed to improve social and object memories. These results support the hypothesis that exposure to an immune challenge during puberty reduces at least some of the cognitive effects of estradiol. Moreover, these results support the idea that pubertal immune challenge compromises a wide variety of behavioral influences of ovarian hormones.
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影响因子：
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作者：
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通讯作者：
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