Determinants of Test Variability in Scotopic Microperimetry: Effects of Dark Adaptation and Test Indices.
Determinants of Test Variability in Scotopic Microperimetry: Effects of Dark Adaptation and Test Indices.
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DOI：
10.1167/tvst.10.1.26
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发表时间：
2021-01
影响因子：
3
通讯作者：
Crabb DP
中科院分区：
文献类型：
--
作者：
Montesano G;Naska TK;Higgins BE;Wright DM;Hogg RE;Crabb DP
探讨不同暗适应条件和可靠性指标对双色暗视微视野检查变异性的影响。我们分析了22名视觉健康成年人的数据。在10、20或30分钟的暗适应时间后，用两种波长刺激，青色（505 nm）和红色（627 nm）进行暗视微视野检查（黄斑完整性评估微视野检查，CenterVue，Padua，意大利）。所有检验均重复两次，以使用Bland-Altman图测量重测变异性。我们还提供了一种基于来自设备的响应数据（按钮按压）更准确地量化假阳性（FP）响应的方法，类似于标准静态视野检查中使用的FP响应。还提取了固定稳定性（95%双变量轮廓椭圆面积）和盲点响应的数据。通过线性混合效应模型量化了它们与测量灵敏度（分贝）和重测变异性的关系。暗适应对青色刺激的敏感度有显著影响（P < 0.001），但对红色刺激无影响。在这三个指标中，新FP反应显示出与重测变异性的最佳关联，并且是所有测试中唯一持续显著的预测因子（P < 0.01）。暗适应协议应仔细标准化暗视测试，特别是如果使用青色刺激。建议的FP响应应用于评估微视野检查的可靠性，而不是其他指标。我们开发了一种方法来计算一个更准确的估计FP的反应，使用数据提供给所有的研究人员，推广到所有黄斑完整性评估微周长测试。
To test the effect of different dark adaptation conditions and reliability indices on the variability of two color scotopic microperimetry. We analyzed data from 22 consecutive visually healthy adults. Scotopic microperimetry was performed (Macular Integrity Assessment microperimeter, CenterVue, Padua, Italy) with two wavelength stimuli, cyan (505 nm) and red (627 nm), after a dark adaptation time of 10, 20, or 30 minutes. All tests were repeated twice to measure test–retest variability with Bland–Altman plots. We also provide a method to more accurately quantify the false-positive (FP) responses based on response data (button pressing) from the device, similar to FP responses used in standard static perimetry. Data on fixation stability (95% bivariate contour ellipse area) and blind spot responses were also extracted. Their relationship with measured sensitivity (in decibels) and test–retest variability was quantified through linear mixed effect models. Dark adaptation had a significant effect on the sensitivity (dB) measured with the cyan stimulus (P < 0.001), but no effect on the red stimulus. Of the three metrics, the novel FP responses showed the best association with test–retest variability and was the only predictor consistently significant for all tests (P < 0.01). Dark adaptation protocols should be carefully standardized for scotopic testing, especially if a cyan stimulus is used. The proposed FP responses should be used to assess reliability of microperimetry examinations instead of other metrics. We developed a method to calculate a more accurate estimate of the FP responses using data available to all researchers, generalizable to all Macular Integrity Assessment microperimeter tests.
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