Pain mechanisms: a commentary on concepts and issues.
Pain mechanisms: a commentary on concepts and issues.
复制标题
DOI：
10.1016/j.pneurobio.2011.03.001
复制
发表时间：
2011-06
影响因子：
6.7
通讯作者：
Perl ER
中科院分区：
文献类型：
--
作者：
Perl ER
这篇关于疼痛神经机制的评论旨在为那些不在哺乳动物躯体感觉领域工作的读者提供视角。这不是一个全面的文献综述。该组织是历史性的编年史思想的演变。其目的是提醒人们注意概念的来源以及各种想法如何随着时间的推移而发展。将疼痛概念联系起来的一个困难是，这个术语被用来指人类和动物的反应，从保护性脊髓反射到复杂的情感行为。因此，“疼痛”相关的神经组织的频谱扩展到多个神经元排列的操作。对疼痛的思考已经在理解生物机制方面取得了进展，特别是神经系统的功能方式。本文集中讨论了从19世纪世纪初到现在信息和概念的演变。主题包括目前活跃的疼痛机制理论的基础假设。最后，简要考虑了当今的问题，例如，慢性疼痛，中枢性疼痛，以及将疼痛视为一种情绪而不是一种感觉。概念的发展表明，当前的争议有着古老的根源，失败的感知往往在似乎被论证和证据平息之后重新出现。
This commentary on ideas about neural mechanisms underlying pain is aimed at providing perspective for a reader who does not work in the field of mammalian somatic sensation. It is not a comprehensive review of the literature. The organization is historical to chronicle the evolution of ideas. The aim is to call attention to source of concepts and how various ideas have fared over time. One difficulty in relating concepts about pain is that the term is used to refer to human and animal reactions ranging from protective spinal reflexes to complex affective behaviors. As a result, the spectrum of “pain”-related neural organization extends to operation of multiple neuronal arrangements. Thinking about pain has shadowed progress in understanding biological mechanisms, in particular the manner of function of nervous systems. This essay concentrates on the evolution of information and concepts from the early 19th century to the present. Topics include the assumptions underlying currently active theories about pain mechanisms. At the end, brief consideration is given to present-day issues, e.g., chronic pain, central pain, and the view of pain as an emotion rather than a sensation. The conceptual progression shows that current controversies have old roots and that failed percepts often resurface after seemingly having been put to rest by argument and evidence.
登录
查看更多内容
影响因子：
5.5
作者：
Adrian, ED;Cattell, M;Hoagland, H
通讯作者：
Hoagland, H
影响因子：
5.5
作者：
Adrian, ED;Zotterman, Y
通讯作者：
Zotterman, Y
影响因子：
5.5
作者：
Adrian, ED
通讯作者：
Adrian, ED
影响因子：
5.5
作者：
Adrian, ED
通讯作者：
Adrian, ED
影响因子：
5.5
作者：
Adrian, E. D.;Bronk, D. W.
通讯作者：
Bronk, D. W.