Evolution, regulation, and function of porcine selenogenome.
Evolution, regulation, and function of porcine selenogenome.
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猪硒基因组的进化、调控和功能。
DOI：
10.1016/j.freeradbiomed.2018.04.560
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发表时间：
2018-11-01
影响因子：
7.4
通讯作者：
Lei XG
中科院分区：
文献类型：
--
作者：
Chen XD;Zhao ZP;Zhou JC;Lei XG
尽管猪是人类营养和医学的优秀模型，而且猪肉是世界上广泛消费的肉类，但对家猪的硒蛋白调节和功能的研究比啮齿动物或人类要少得多。从系统发育角度来看，25 种已鉴定的猪硒蛋白分为两个原始类群，并且可能进一步分为三个平行分支。尽管与人类和啮齿类动物的硒蛋白组高度相似，但猪的硒蛋白组在八个家养物种中表现出与羊和牛最接近的进化关系。猪各组织中 25 种猪硒蛋白中的 2/3 的表达（mRNA、蛋白质和/或酶活性）受到日粮硒摄入量的影响，其中 14 种表现出对高脂肪饮食的反应。当膳食缺硒主要下调某些含硒蛋白的表达时，膳食硒过量对其表达产生相当不同的影响。给猪摄入过量硒会通过影响参与葡萄糖、脂质和蛋白质代谢的关键基因和（或）蛋白质，导致肝脏和肌肉中的高胰岛素血症，以及脂质积累和蛋白质增加。总之，猪硒蛋白的表达对膳食硒和脂肪摄入量高度敏感，并且与啮齿动物和人类一样参与体内葡萄糖、脂质和蛋白质代谢。
Much less research on regulation and function of selenoproteins has been conducted in domestic pigs than in rodents or humans, although pigs are an excellent model of human nutrition and medicine and pork is a widely consumed meat in the world. Phylogenetically, the 25 identified porcine selenoproteins fell into two primitive groups, and might be further divided into three parallel branches. Despite a high similarity to that of humans and rodents, the porcine selenoproteome exhibited the closest evolutionary relationship with that of sheep and cattle among eight domestic species. Expression (mRNA, protein, and/or enzyme activity) of 2/3 of the 25 porcine selenoproteins in various tissues of pigs was affected by dietary Se intakes, and 14 of them showed responses to a high fat diet. When dietary Se deficiency mainly down-regulated the expression of selected selenoproteins, dietary Se excess exerted rather diverse effects on their expression. Overdosing pigs with dietary Se induced hyperinsulinemia, along with lipid accumulation and protein increase, in the liver and muscle by affecting key genes and(or) proteins involved in the metabolisms of glucose, lipid, and protein. In conclusion, expression of porcine selenoproteins was highly responsive to dietary Se and fat intakes, and was involved in body glucose, lipid, and protein metabolism as those of rodents and humans.
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影响因子：
3.7
作者：
Han SJ;Lee BC;Yim SH;Gladyshev VN;Lee SR
通讯作者：
Lee SR
DOI：
10.1073/pnas.0914625107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Hancock, Angela M.;Witonsky, David B.;Di Rienzo, Anna
通讯作者：
Di Rienzo, Anna
影响因子：
64.8
作者：
通讯作者：
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脊椎动物和哺乳动物硒蛋白质组的组成和进化
影响因子：
3.7
作者：
Mariotti M;Ridge PG;Zhang Y;Lobanov AV;Pringle TH;Guigo R;Hatfield DL;Gladyshev VN
通讯作者：
Gladyshev VN
影响因子：
56.9
作者：
Kryukov, GV;Castellano, S;Gladyshev, VN
通讯作者：
Gladyshev, VN