Additive-free preparation of hemodialysis membranes from block copolymers of polysulfone and polyethylene glycol
Additive-free preparation of hemodialysis membranes from block copolymers of polysulfone and polyethylene glycol
复制标题
聚砜和聚乙二醇嵌段共聚物无添加剂制备血液透析膜
DOI：
10.1016/j.memsci.2020.118690
复制
发表时间：
2021-01
影响因子：
9.5
通讯作者：
Wang Yong
中科院分区：
文献类型：
--
作者：
Zhong Dinglei;Wang Zhaogen;Wang Yong
血液透析膜已广泛应用于慢性肾脏疾病的治疗。然而，与普通的血液透析膜一样，聚砜基膜面临着复杂的改性，以提高血液相容性和添加剂浸出的安全性问题。面对这些挑战，本文通过无溶剂诱导相分离(NIPS)的方法，在不使用任何添加剂的情况下，将嵌段共聚物聚砜-嵌段-聚乙二醇酯(PSF-b-PEG)引入到血液透析膜中，制备了具有良好血液相容性和生物相容性的血液透析膜。研究了PSF-b-PEG膜的体外相容性和膜的性能，以及蛋白质吸附、溶血、血小板黏附、超滤系数、溶质排斥和毒素清除等性能。由于表面存在亲水性和生物相容性的聚乙二醇膜，PSF-b-PEG膜表现出比传统膜更优越的血液透析性能，显示了其在血液透析中的应用前景。
Hemodialysis membranes have been widely used for the treatment of chronic kidney disease. However, as common hemodialysis membranes, polysulfone based membranes are suffering from complicated modification to improve hemocompatibility and safety issues of additive leaching-out. Facing these challenges, here hemodialysis membranes with excellent hemocompatibility and biocompatibility were fabricated by nonsolvent induced phase separation (NIPS) of a block copolymer, polysulfone-block-poly(ethylene glycol) (PSF-b-PEG), without using any additives. During NIPS, mesopores were formed throughout the membrane and the PEG chains were preferentially enriched on surfaces, thus improving the hydrophilicity.In-vitrocompatibility and performance of the PSF-b-PEG membranes as well as protein adsorption, hemolysis, platelet adhesion, ultrafiltration coefficient, solute rejection and toxin clearance were studied. Due to the intrinsic existence of hydrophilic and biocompatible PEG on surface, the PSF-b-PEG membranes exhibited superior hemodialysis performances than traditional membranes, demonstrating their promise for hemodialysis.
登录
查看更多内容
影响因子：
9.5
作者：
Caini Liu;Wang Wenyi;Yanling Li;Fangyan Cui;C. Xie;Liuyong Zhu;Bojin Shan
通讯作者：
Caini Liu;Wang Wenyi;Yanling Li;Fangyan Cui;C. Xie;Liuyong Zhu;Bojin Shan
DOI：
10.1002/9781119413172.ch6
发表时间：
2019-06
期刊：
Renal Nursing
影响因子：
--
作者：
N. Thomas
通讯作者：
N. Thomas
DOI：
10.1163/092050610x517220
发表时间：
2010-01
期刊：
Journal of Biomaterials Science, Polymer Edition
影响因子：
--
作者：
Masaru Tanaka;A. Mochizuki
通讯作者：
Masaru Tanaka;A. Mochizuki
影响因子：
8.6
作者：
O. T. Beek;D. Pavlenko;M. Suck;S. Helfrich;L. Bolhuis-Versteeg;D. Snisarenko;C. Causserand;P. Bacchin;P. Aimar;R. Oerle;R. Wetzels;P. Verhezen;Y. Henskens;D. Stamatialis
通讯作者：
O. T. Beek;D. Pavlenko;M. Suck;S. Helfrich;L. Bolhuis-Versteeg;D. Snisarenko;C. Causserand;P. Bacchin;P. Aimar;R. Oerle;R. Wetzels;P. Verhezen;Y. Henskens;D. Stamatialis
影响因子：
9.5
作者：
Gao, Ailin;Liu, Fu;Xue, Lixin
通讯作者：
Xue, Lixin