Responsiveness of eyes with polypoidal choroidal vasculopathy with choroidal hyperpermeability to intravitreal ranibizumab.
Responsiveness of eyes with polypoidal choroidal vasculopathy with choroidal hyperpermeability to intravitreal ranibizumab.
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DOI：
10.1186/1471-2415-13-43
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发表时间：
2013-08-20
影响因子：
2
通讯作者：
Arimura N
中科院分区：
文献类型：
--
作者：
Sonoda S;Sakamoto T;Otsuka H;Yoshinaga N;Yamashita T;Ki-I Y;Okubo A;Yamashita T;Arimura N
从介入免疫学角度探讨血管内皮生长因子（VEGF）在息肉状脉络膜血管病变（PCV）中的作用。根据吲哚菁绿色血管造影结果，将PCV患者分为脉络膜通透性增高组（HP组）和脉络膜通透性正常组（NP组）。使用Fleiss kappa评价评价者间一致率。患者接受玻璃体内雷珠单抗（IVB）治疗。采用光学相干断层扫描仪测量治疗前和治疗后7天的中心脉络膜厚度和中心凹厚度（CFT）。在诊断为PCV的57只连续眼睛中，42名患者的42只眼睛符合入选标准（HP组21只眼睛vs NP组21只眼睛）。HP组的中央脉络膜厚度显著厚于NP组（P <0.001，Mann-Whitney U检验）。评定者间一致性较高，Fleiss' kappa = 0.95，P < .0001。HP组的CFT降低百分比（14.0%）显著低于NP组（20.4%; P = 0.013，Mann-Whitney U检验）。与脉络膜通透性过高相关的PCV眼睛可能与VEGF相关的病理学没有很强的相关性，并且可能对抗VEGF单药治疗没有有利的反应。
To determine the role played by vascular endothelial growth factor (VEGF) in polypoidal choroidal vasculopathy (PCV) based on an interventional immunology theory. Eyes with PCV were divided in a masked fashion into those with choroidal hyperpermeability (HP group) and those with normal choroidal permeability (NP group) based on the indocyanine green angiograms. The inter-rater agreement rate was evaluated using Fleiss’ kappa. Patients were treated by intravitreal ranibizumab (IVB). The central choroidal thickness and central foveal thickness (CFT) at the baseline and 7 days after the treatment were measured by optical coherence tomography. Among the 57 consecutive eyes diagnosed with PCV, 42 eyes of 42 patients met the inclusion criteria (21 eyes/HP group vs 21 eyes /NP group). Central choroidal thickness in HP group was significantly thicker than that in the NP group (P < .001, Mann–Whitney U test). The inter-rater agreement was high with a Fleiss’ kappa = 0.95, P < .0001. The percentage reduction in the CFT in HP group (14.0%) was significantly less than that in NP group (20.4%; P = .013, Mann–Whitney U test). Eyes with PCV that are associated with choroidal hyper-permeability may not be strongly associated with VEGF-related pathology, and may not respond favorably to anti-VEGF monotherapy.
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典型的新生血管相关的黄斑变性和多型脉络膜脉络膜病变的玻璃体内ranibizumab的早期反应。
影响因子：
1.9
作者：
Matsumiya W;Honda S;Bessho H;Kusuhara S;Tsukahara Y;Negi A
通讯作者：
Negi A
影响因子：
4.2
作者：
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通讯作者：
Kinoshita, Shigeru
DOI：
10.1097/iae.0b013e31823beb14
发表时间：
2012-06-01
影响因子：
3.3
作者：
Khan, Samira;Engelbert, Michael;Freund, K. Bailey
通讯作者：
Freund, K. Bailey
影响因子：
4.1
作者：
Chan, WM;Lam, DSC;Chan, CKM
通讯作者：
Chan, CKM
影响因子：
4.2
作者：
Manjunath, Varsha;Goren, Jordana;Fujimoto, James G.;Duker, Jay S.
通讯作者：
Duker, Jay S.