The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function.
The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function.
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自由运动模式Y迷宫：工作记忆和执行功能的跨物种测量。
DOI：
10.3758/s13428-020-01452-x
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发表时间：
2021-04
影响因子：
5.4
通讯作者：
Parker MO
中科院分区：
文献类型：
--
作者：
Cleal M;Fontana BD;Ranson DC;McBride SD;Swinny JD;Redhead ES;Parker MO
许多神经退行性和精神疾病与执行功能如工作记忆和认知灵活性的缺陷有关。开发有效的疾病治疗方法的进展可能受益于针对这些认知障碍，其成功取决于开发具有验证行为测定的动物模型。斑马鱼为研究复杂的大脑疾病提供了一个有前途的模型，但缺乏评估执行功能的任务。自由运动模式（FMP）Y-迷宫结合了普通Y-迷宫测定的方面，其利用生物体探索未知环境的内在动机，并基于一系列连续的二选一辨别进行分析。我们验证的任务作为工作记忆和执行功能的衡量标准，通过比较任务的性能参数在成年斑马鱼治疗的范围内已知损害工作记忆和认知灵活性的多巴胺能，胆碱能和多巴胺能药物。我们证明了跨物种的有效性的任务，通过评估性能参数的适应版本的任务，小鼠和果蝇，最后在人类的虚拟版本，并确定显着的共性脊椎动物物种的迷宫导航。总之，我们的研究结果表明，FMP Y-迷宫是一种敏感的测定方法，用于评估从无脊椎动物到人类的各种物种的工作记忆和认知灵活性，提供了一种简单且广泛适用的具有特殊翻译相关性的行为测定。本文的在线版本（10.3758/s13428-020-01452-x）包含补充材料，可供授权用户使用。
Numerous neurodegenerative and psychiatric disorders are associated with deficits in executive functions such as working memory and cognitive flexibility. Progress in developing effective treatments for disorders may benefit from targeting these cognitive impairments, the success of which is predicated on the development of animal models with validated behavioural assays. Zebrafish offer a promising model for studying complex brain disorders, but tasks assessing executive function are lacking. The Free-movement pattern (FMP) Y-maze combines aspects of the common Y-maze assay, which exploits the inherent motivation of an organism to explore an unknown environment, with analysis based on a series of sequential two-choice discriminations. We validate the task as a measure of working memory and executive function by comparing task performance parameters in adult zebrafish treated with a range of glutamatergic, cholinergic and dopaminergic drugs known to impair working memory and cognitive flexibility. We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila, and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species’ navigation of the maze. Together, our results demonstrate that the FMP Y-maze is a sensitive assay for assessing working memory and cognitive flexibility across species from invertebrates to humans, providing a simple and widely applicable behavioural assay with exceptional translational relevance. The online version of this article (10.3758/s13428-020-01452-x) contains supplementary material, which is available to authorized users.
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影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
DOI：
10.1017/s1461145705005407
发表时间：
2006-04-01
影响因子：
4.8
作者：
Ellis, JR;Ellis, KA;Nathan, PJ
通讯作者：
Nathan, PJ
DOI：
10.1007/7854_2016_467
发表时间：
2018-01-01
期刊：
BEHAVIORAL NEUROSCIENCE OF LEARNING AND MEMORY
影响因子：
--
作者：
Blake, M. G.;Boccia, M. M.
通讯作者：
Boccia, M. M.
影响因子：
2.7
作者：
Cognato, Giana de P.;Bortolotto, Josiane W.;Bonan, Carla D.
通讯作者：
Bonan, Carla D.
DOI：
10.1111/gbb.12268
发表时间：
2016-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Cope ZA;Powell SB;Young JW
通讯作者：
Young JW