Neuromodulatory signaling in hippocampus-dependent memory retrieval.
Neuromodulatory signaling in hippocampus-dependent memory retrieval.
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DOI：
10.1002/hipo.22394
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发表时间：
2015-04
期刊：
影响因子：
3.5
通讯作者：
Thomas, Steven A.
中科院分区：
文献类型：
--
作者：
Thomas, Steven A.
在理解记忆获得和巩固背后的分子信号事件方面已经取得了相当大的进展。相比之下，人们对记忆提取知之甚少，尽管它对利用学习的信息是必要的。这篇综述集中于神经调节和细胞内信号事件，这些信号事件是由海马体介导的记忆恢复的基础，目前关于海马体的信息最多。在神经调节剂中，肾上腺素能信号是恢复各种类型的海马体依赖记忆所必需的。虽然它们有助于获得和/或巩固，但胆碱能和多巴胺能信号一般不需要检索。有趣的是，虽然提取不是必需的，但5-羟色胺和阿片类信号实际上可能会限制记忆的提取。组胺和非阿片类神经肽的作用目前尚不清楚，但可能。肾上腺素能信号在恢复过程中的一个关键效应是减少由β-1受体、环磷酸腺苷、蛋白激酶A、EPAC以及可能的ERK介导的慢后超极化。相反，应激和糖皮质激素通过降低环磷酸腺苷，部分通过激活β2-肾上腺素能受体来损害重现。临床上，阿尔茨海默病、唐氏综合症、抑郁症和创伤后应激障碍都会发生神经调节信号和记忆恢复的变化，最近的证据已经开始将神经调节信号的变化与记忆恢复的影响联系起来。
Considerable advances have been made toward understanding the molecular signaling events that underlie memory acquisition and consolidation. In contrast, less is known about memory retrieval, despite its necessity for utilizing learned information. This review focuses on neuromodulatory and intracellular signaling events that underlie memory retrieval mediated by the hippocampus, for which the most information is currently available. Among neuromodulators, adrenergic signaling is required for the retrieval of various types of hippocampus-dependent memory. Although they contribute to acquisition and/or consolidation, cholinergic and dopaminergic signaling are generally not required for retrieval. Interestingly, while not required for retrieval, serotonergic and opioid signaling may actually constrain memory retrieval. Roles for histamine and non-opioid neuropeptides are currently unclear but possible. A critical effector of adrenergic signaling in retrieval is reduction of the slow afterhyperpolarization mediated by β1 receptors, cyclic AMP, protein kinase A, Epac, and possibly ERK. In contrast, stress and glucocorticoids impair retrieval by decreasing cyclic AMP, mediated in part by the activation of β2-adrenergic receptors. Clinically, alterations in neuromodulatory signaling and in memory retrieval occur in Alzheimer’s disease, Down syndrome, depression, and post-traumatic stress disorder, and recent evidence has begun to link changes in neuromodulatory signaling with effects on memory retrieval.
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从分子到全脑网络的睡眠，可塑性和记忆力。
影响因子：
9.2
作者：
Abel, Ted;Havekes, Robbert;Saletin, Jared M.;Walker, Matthew P.
通讯作者：
Walker, Matthew P.
影响因子：
5.3
作者：
Bekinschtein, Pedro;Constanza Renner, Maria;Weisstaub, Noelia
通讯作者：
Weisstaub, Noelia
影响因子：
2.9
作者：
Acevedo, SF;Ohtsu, H;Raber, J
通讯作者：
Raber, J
影响因子：
2.9
作者：
ALTMAN, HJ;NORMILE, HJ;AZMITIA, EC
通讯作者：
AZMITIA, EC
DOI：
10.1037/h0077579
发表时间：
1979-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, CA
通讯作者：
BARNES, CA