Language and reading skills in school-aged children and adolescents born preterm are associated with white matter properties on diffusion tensor imaging.
Language and reading skills in school-aged children and adolescents born preterm are associated with white matter properties on diffusion tensor imaging.
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DOI：
10.1016/j.neuropsychologia.2012.10.014
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发表时间：
2012-12
期刊：
影响因子：
2.6
通讯作者：
Yeom KW
中科院分区：
文献类型：
--
作者：
Feldman HM;Lee ES;Yeatman JD;Yeom KW
早产儿有语言和阅读障碍的风险。他们还面临着脑白质损伤的风险。这项研究的目的是确定语言和阅读技能的表现是否与早产儿和足月儿的脑白质特性有关。对孕36周前出生的23例(平均年龄12.5±2.0岁，胎龄28.7±2.5周，出生体重1184±431g)和孕37周后出生的对照组(19例，13.1±2.1岁，39.3±1.0周，3178±413g)进行了一系列的语言和阅读测试。弥散张量成像(DTI)扫描使用基于轨迹的空间统计处理，以生成在参与者之间在解剖学上具有可比性的核心白质骨骼。分数各向异性(FA)是分析中使用的扩散属性。在全学期组中，整个FA框架中没有一个区域与语言和阅读有关。在早产儿组，FA骨架的区域与言语智商、语言加工速度、句法理解和解码显著相关。结合起来，这些区域形成了一张由两个半球以及腹侧和背侧流15个区域上的22个星团组成的合成地图。早产儿组的ROI分析发现，这些区域中的几个也与接受性词汇、言语记忆和阅读理解呈正相关。同一地区中的一些地区在全期组内显示出微弱的负相关性。在早产儿组中，探索性多元回归发现，特定的白质通路与语言处理和阅读的不同方面有关，解释了27%-44%的变异。研究结果表明，一组早产儿但不是足月儿在语言和阅读方面的表现较好，与双侧和分布的白质网络的部分各向异性较高有关。
Children born preterm are at risk for deficits in language and reading. They are also at risk for injury to the white matter of the brain. The goal of this study was to determine whether performance in language and reading skills would be associated with white matter properties in children born preterm and full-term. Children born before 36 weeks gestation (n=23, mean±SD age 12.5±2.0 years, gestational age 28.7±2.5 weeks, birth weight 1184±431 g) and controls born after 37 weeks gestation (n=19, 13.1±2.1 years, 39.3±1.0 weeks, 3178±413 g) underwent a battery of language and reading tests. Diffusion Tensor Imaging (DTI) scans were processed using Tract-Based Spatial Statistics to generate a core white matter skeleton that was anatomically comparable across participants. Fractional anisotropy (FA) was the diffusion property used in analyses. In the full-term group, no regions of the whole FA-skeleton were associated with language and reading. In the preterm group, regions of the FA-skeleton were significantly associated with verbal IQ, linguistic processing speed, syntactic comprehension, and decoding. Combined, the regions formed a composite map of 22 clusters on 15 tracts in both hemispheres and in the ventral and dorsal streams. ROI analyses in the preterm group found that several of these regions also showed positive associations with receptive vocabulary, verbal memory, and reading comprehension. Some of the same regions showed weak negative correlations within the full-term group. Exploratory multiple regression in the preterm group found that specific white matter pathways were related to different aspects of language processing and reading, accounting for 27–44% of the variance. The findings suggest that higher performance in language and reading in a group of preterm but not full-term children is associated with higher fractional anisotropy of a bilateral and distributed white matter network.
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