Observed Hearing Loss and Incident Dementia in a Multiethnic Cohort.
Observed Hearing Loss and Incident Dementia in a Multiethnic Cohort.
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DOI：
10.1111/jgs.14848
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发表时间：
2017-08
影响因子：
6.3
通讯作者：
Schupf N
中科院分区：
文献类型：
--
作者：
Golub JS;Luchsinger JA;Manly JJ;Stern Y;Mayeux R;Schupf N
听力损失（HL）可能是痴呆症的一个危险因素；然而，这一发现需要复制并扩展到不同种族的样本才能具有普遍性。本研究的目的是确定多种族人群中观察到的听力损失 (OHL) 是否与痴呆症相关。华盛顿高地-因伍德哥伦比亚老龄化项目 (WHICAP) 曼哈顿北部社区受试者的前瞻性流行病学队列研究，是一项关于种族多元化社区中老龄化和痴呆症的纵向研究 (n=1,881)。 OHL 是根据检查员的观察或自我报告的助听器使用情况来定义的。痴呆症的诊断是由共识小组使用标准研究标准做出的。使用 Cox 比例风险模型来检查基线 OHL 与痴呆风险的关系（平均 7.3 年，范围，0.9-20，SD=4.4）。 OHL 与 1.69 (95% CI=1.3-2.3; p<0.01) 倍的痴呆事件风险相关，根据人口统计、心血管危险因素、APOE4 基因型和中风进行调整。按种族分层时，OHL 与痴呆症的相关性在所有组中均升高，但仅在非裔美国人中具有统计学意义（HR=2.62，95% CI=1.5-4.5；p<0.01）。在多种族队列中，OHL 与痴呆风险增加相关。需要更多的研究来确定 HL 是否会导致痴呆，以及治疗 HL 是否可以降低痴呆的风险。
Hearing loss (HL) may be a risk factor for incident dementia; however, this finding needs replication and extension to ethnically diverse samples for generalizability. The objective of this study was to determine whether observed hearing loss (OHL) is associated with incident dementia in a multiethnic population. Prospective epidemiologic cohort study Community of Northern Manhattan Subjects of the Washington Heights-Inwood Columbia Aging Project (WHICAP), a longitudinal study on aging and dementia in an ethnically diverse community (n=1,881). OHL was defined when observed by the examiner or by self-reported hearing aid use. Diagnoses of dementia were made by a consensus panel using standard research criteria. A Cox proportional hazards model was used to examine the relation of OHL at baseline to risk of incident dementia (mean 7.3 years, range, 0.9-20, SD=4.4). OHL was associated with 1.69 (95% CI=1.3-2.3; p<0.01) times the risk of incident dementia adjusting for demographics, cardiovascular risk factors, APOE4 genotype, and stroke. When stratifying by race, the association of OHL with incident dementia was elevated in all groups but was statistically significant only among African Americans (HR=2.62, 95% CI=1.5-4.5; p<0.01). OHL was associated with an increased risk of incident dementia in a multiethnic cohort. More study is needed to determine if HL contributes to dementia, and if treating HL can reduce the risk of dementia.
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影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
168.9
作者：
Fratiglioni, L;Wang, HX;Winblad, B
通讯作者：
Winblad, B
DOI：
10.1093/gerona/glr115
发表时间：
2011-10-01
影响因子：
5.1
作者：
Lin, Frank R.
通讯作者：
Lin, Frank R.
DOI：
10.1097/mao.0000000000000313
发表时间：
2014-06
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Gurgel RK;Ward PD;Schwartz S;Norton MC;Foster NL;Tschanz JT
通讯作者：
Tschanz JT
影响因子：
--
作者：
Gates, George A.;Anderson, Melissa L.;McCurry, Susan M.;Feeney, M. Patrick;Larson, Eric B.
通讯作者：
Larson, Eric B.