Ferulic Acid: therapeutic potential through its antioxidant property.
Ferulic Acid: therapeutic potential through its antioxidant property.
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阿魏酸：通过其抗氧化特性的治疗潜力。
DOI：
10.3164/jcbn.40.92
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发表时间：
2007-03
影响因子：
2.4
通讯作者：
Menon, Venugopal P.
中科院分区：
文献类型：
--
作者：
Srinivasan, Marimuthu;Sudheer, Adluri R.;Menon, Venugopal P.
使用源自膳食成分的植物化学物质来对抗人类疾病引起了公众和科学界的极大兴趣。它们是植物中天然存在的物质。阿魏酸 (FA) 是一种植物化学物质，常见于西红柿、甜玉米和米糠等水果和蔬菜中。它源自植物中通过莽草酸途径代谢苯丙氨酸和酪氨酸。它对癌症、糖尿病、心血管和神经退行性疾病等多种疾病具有广泛的治疗作用。人们主张这种酚类化合物对人类健康具有广泛的有益活性，至少部分是因为其强大的抗氧化活性。 FA 是一种酚类化合物，是一种强膜抗氧化剂，已知对人类健康有积极影响。 FA是一种有效的自由基清除剂，已在某些国家被批准作为食品添加剂以防止脂质过氧化。有效清除超氧阴离子自由基，抑制脂质过氧化。它凭借其结构中的酚羟基而具有抗氧化性能。 FA 的羟基和苯氧基提供电子来猝灭自由基。酚基又形成醌甲基化物中间体，通过胆汁排出。过去几十年来，人们致力于 FA 抗氧化特性的深入研究。因此，本综述探讨了 FA 的抗氧化特性的机制及其在治疗各种疾病中的可能作用。
There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice bran. It arises from metabolism of phenylalanine and tyrosine by Shikimate pathway in plants. It exhibits a wide range of therapeutic effects against various diseases like cancer, diabetes, cardiovascular and neurodegenerative. A wide spectrum of beneficial activity for human health has been advocated for this phenolic compound, at least in part, because of its strong antioxidant activity. FA, a phenolic compound is a strong membrane antioxidant and known to positively affect human health. FA is an effective scavenger of free radicals and it has been approved in certain countries as food additive to prevent lipid peroxidation. It effectively scavenges superoxide anion radical and inhibits the lipid peroxidation. It possesses antioxidant property by virtue of its phenolic hydroxyl group in its structure. The hydroxy and phenoxy groups of FA donate electrons to quench the free radicals. The phenolic radical in turn forms a quinone methide intermediate, which is excreted via the bile. The past few decades have been devoted to intense research on antioxidant property of FA. So, the present review deals with the mechanism of antioxidant property of FA and its possible role in therapeutic usage against various diseases.
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DOI：
10.1111/j.1349-7006.2001.tb01109.x
发表时间：
2001-04
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Han BS;Park CB;Takasuka N;Naito A;Sekine K;Nomura E;Taniguchi H;Tsuno T;Tsuda H
通讯作者：
Tsuda H
DOI：
10.1006/bbrc.1994.2544
发表时间：
1994-10-28
影响因子：
3.1
作者：
INOUE, M;SUZUKI, R;YABU, Y
通讯作者：
YABU, Y
DOI：
10.1080/07315724.2000.10718968
发表时间：
2000-06-01
影响因子：
3.5
作者：
Jacobs, DR;Pereira, MA;Kushi, LH
通讯作者：
Kushi, LH
影响因子：
4.2
作者：
Adam, A;Crespy, V;Rémésy, C
通讯作者：
Rémésy, C
DOI：
10.3181/00379727-218-44282a
发表时间：
1998-06-01
影响因子：
--
作者：
Beecher, GR
通讯作者：
Beecher, GR