Neural Basis of Action Understanding: Evidence from Sign Language Aphasia.
Neural Basis of Action Understanding: Evidence from Sign Language Aphasia.
复制标题
DOI：
10.1080/02687038.2013.812779
复制
发表时间：
2013
期刊：
影响因子：
2
通讯作者：
Hickok G
中科院分区：
文献类型：
--
作者：
Rogalsky C;Raphel K;Tomkovicz V;O'Grady L;Damasio H;Bellugi U;Hickok G
动作理解的神经基础是一个争论不休的问题。镜像神经元的描述认为，额顶回路中的运动模拟对于包括语音理解在内的动作理解至关重要，而其他人则强调颞叶的腹侧流。来自语音的证据有力地支持腹侧流的说法，但另一方面，来自手动手势理解的证据(例如，肢体失用)导致了相互矛盾的发现。在这里，我们提出了手语理解的损伤分析。手语是研究镜像系统功能的一个很好的模型，因为它弥合了镜像神经元最有特点的视觉-人工系统和代表镜像神经元研究理论目标的语言系统之间的差距。21名患有局灶性皮质损伤的终生聋人完成了两项任务：一项涉及对个别手势的理解，另一项涉及对手语句子(命令)的理解。受试者的病变，如MRI或CT扫描所示，被映射到一个模板大脑上，以探索病变位置与手势理解测量之间的关系。单项手势理解能力不受左脑损害的影响。句子符号理解障碍与左侧颞顶损害相关。我们发现，在这两个理解任务中，左额叶镜像系统相关区域的损伤与缺陷没有关联。我们的结论是，镜像系统并没有关键地参与到行动理解中来。
The neural basis of action understanding is a hotly debated issue. The mirror neuron account holds that motor simulation in fronto-parietal circuits is critical to action understanding including speech comprehension, while others emphasize the ventral stream in the temporal lobe. Evidence from speech strongly supports the ventral stream account, but on the other hand, evidence from manual gesture comprehension (e.g., in limb apraxia) has led to contradictory findings. Here we present a lesion analysis of sign language comprehension. Sign language is an excellent model for studying mirror system function in that it bridges the gap between the visual-manual system in which mirror neurons are best characterized and language systems which have represented a theoretical target of mirror neuron research. Twenty-one life long deaf signers with focal cortical lesions performed two tasks: one involving the comprehension of individual signs and the other involving comprehension of signed sentences (commands). Participants' lesions, as indicated on MRI or CT scans, were mapped onto a template brain to explore the relationship between lesion location and sign comprehension measures. Single sign comprehension was not significantly affected by left hemisphere damage. Sentence sign comprehension impairments were associated with left temporal-parietal damage. We found that damage to mirror system related regions in the left frontal lobe were not associated with deficits on either of these comprehension tasks. We conclude that the mirror system is not critically involved in action understanding.
登录
查看更多内容
影响因子：
3.2
作者：
Hickok G
通讯作者：
Hickok G
影响因子：
2.5
作者：
Hickok, Gregory;Costanzo, Maddalena;Capasso, Rita;Miceli, Gabriele
通讯作者：
Miceli, Gabriele
影响因子：
14.5
作者：
Kalenine, Solene;Buxbaum, Laurel J.;Coslett, Harry Branch
通讯作者：
Coslett, Harry Branch
影响因子：
5.7
作者：
Emmorey, Karen;Mehta, Sonya;Grabowski, Thomas J.
通讯作者：
Grabowski, Thomas J.
影响因子：
3.4
作者：
Dronkers, NF;Wilkins, DP;Jaeger, JJ
通讯作者：
Jaeger, JJ