Multiplexed microarrays based on optically encoded microbeads.
Multiplexed microarrays based on optically encoded microbeads.
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DOI：
10.1007/s10544-018-0314-4
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发表时间：
2018-08-07
影响因子：
2.8
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Vafajoo A;Rostami A;Foroutan Parsa S;Salarian R;Rabiee N;Rabiee G;Rabiee M;Tahriri M;Vashaee D;Tayebi L;Hamblin MR
近年来，人们对光学编码或标记的功能化微珠作为捕获蛋白质或核苷酸的固体支持平台越来越感兴趣，这些蛋白质或核苷酸可作为各种疾病的生物标志物。基于光学编码微球的多重技术（悬浮阵列或平面阵列）使得观察与特定疾病相关的生物标志物相对较小的变化成为可能。如果能够在早期阶段识别这些变化，则可以在仍然有可能进行治愈性治疗的时间点诊断出严重疾病（例如癌症）。由于当前某些疾病诊断方法的总体准确性常常令人失望，因此基于光学编码微珠的多重检测可以在以非侵入性且准确的方式检测疾病生物标志物方面发挥重要作用。然而，基于功能化编码微珠的检测系统仍然是一项新兴技术，未来需要进行更多的研究。这篇综述文章是总结有关诊断微珠最新技术的初步尝试；包括微球组成、合成、编码技术、检测系统和应用。
In recent years, there has been growing interest in optically-encoded or tagged functionalized microbeads as a solid support platform to capture proteins or nucleotides which may serve as biomarkers of various diseases. Multiplexing technologies (suspension array or planar array) based on optically encoded microspheres have made possible the observation of relatively minor changes in biomarkers related to specific diseases. The ability to identify these changes at an early stage may allow the diagnosis of serious diseases (e.g. cancer) at a time-point when curative treatment may still be possible. As the overall accuracy of current diagnostic methods for some diseases is often disappointing, multiplexed assays based on optically encoded microbeads could play an important role to detect biomarkers of diseases in a non-invasive and accurate manner. However, detection systems based on functionalized encoded microbeads are still an emerging technology, and more research needs to be done in the future. This review paper is a preliminary attempt to summarize the state-of-the-art concerning diagnostic microbeads; including microsphere composition, synthesis, encoding technology, detection systems, and applications.
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DOI：
10.1517/17530050802651561
发表时间：
2009-01-01
期刊：
Expert opinion on medical diagnostics
影响因子：
--
作者：
Fritzler, Marvin J;Fritzler, Mark L
通讯作者：
Fritzler, Mark L
DOI：
10.1016/j.cccn.2005.06.023
发表时间：
2006-01
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Dunbar SA
通讯作者：
Dunbar SA
影响因子：
46.9
作者：
Han, MY;Gao, XH;Nie, S
通讯作者：
Nie, S
影响因子：
10.8
作者：
Ding, L;Lee, T;Wang, CH
通讯作者：
Wang, CH
影响因子：
8.4
作者：
Han, Sang Won;Jang, Eunji;Koh, Won-Gun
通讯作者：
Koh, Won-Gun