Surveillance of avirulent Newcastle disease viruses at live bird markets in Eastern China during 2008-2012 reveals a new sub-genotype of class I virus.
Surveillance of avirulent Newcastle disease viruses at live bird markets in Eastern China during 2008-2012 reveals a new sub-genotype of class I virus.
复制标题
2008-2012年对华东地区活禽市场无毒新城疫病毒的监测揭示了I类病毒的新亚基因型。
DOI：
10.1186/s12985-014-0211-2
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发表时间：
2014-12-04
期刊：
影响因子：
4.8
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Zhu J;Xu H;Liu J;Zhao Z;Hu S;Wang X;Liu X
纽卡斯尔病病毒（NDV）可分为I类和II类两个不同的分支。目前，在活禽市场（LBM）中，I类病毒的分子流行病学数据有限。了解I类NDV的基因组和抗原特征可能会为这些病毒的进化动力学提供重要的见解。在这项研究中，对2008年至2012年期间从中国东部的LBM中分离的I类NDV进行了表征。我们的特点是34个I类NDV的遗传和15的34个NDV的病理起源于鹅，鸡和鸭在活禽市场。根据旧的分类系统，2008年至2010年分离的14株菌株中有12株属于亚基因型3b。其余22株在基因型3中形成了一个新的簇，命名为3c亚型。在新的分类体系中，3b亚基因型被划分为1a亚基因型，3c亚基因型被划分为1b亚基因型。鸡源病毒占62%以上（21/34），水禽源病毒仅13株。CK/JS/05/11、CK/JS/06/12与LaSota疫苗株的交叉中和反应显示两者之间存在明显的抗原性差异。目前，3c（或1b）亚型NDV是中国东部LBM最常见的I类病毒株。Ⅰ类NDV已从水禽转移到鸡群中，并在鸡群中广泛传播。
The strains of Newcastle disease virus (NDV) can be divided into two distinct clades: class I and class II. At present, limited molecular epidemiological data are available for the class I virus at live bird markets (LBMs). Knowing the genomic and antigenic characteristics of class I NDVs might provide important insights into the evolution dynamics of these viruses. In this study class I NDVs isolated from LBMs in Eastern China between 2008 and 2012 were characterized. We characterized 34 class I NDVs genetically and 15 of the 34 NDVs pathologically which originated from geese, chickens and ducks at live bird markets. Based on the older classification system, twelve of fourteen strains isolated from 2008 to 2010 belonged to sub-genotype 3b. However, the rest 22 strains formed a separate novel cluster in genotype 3, which was designated as sub-genotype 3c. When based on the new classification system, sub-genotype 3b was classified into sub-genotype 1a and the sub-genotype 3c was classified into sub-genotype 1b. Over 62% (21/34) of the viruses were chicken-origin and only 13 isolates were waterfowl-origin. The Cross-neutralization reactions between CK/JS/05/11, CK/JS/06/12 and the vaccine strain LaSota showed significant antigenic differences between them. Currently, sub-genotype 3c (or 1b) NDVs are the most frequently isolated classI strains at LBMs in Eastern China., and the class I NDVs has transferred from waterfowls to chickens and circulated in chicken flocks extensively.
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