Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice.
Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice.
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直接和间接 5-HT 受体激动剂对 C57 BL/6J 小鼠的运动和垂直活动产生性别特异性影响。
DOI：
10.1016/j.pbb.2009.08.008
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发表时间：
2009-11
影响因子：
3.6
通讯作者：
Jones, Sara R.
中科院分区：
文献类型：
--
作者：
Brookshire, Bethany R.;Jones, Sara R.
关键词：
多巴胺（DA）和5-羟色胺（5-HT）系统具有广泛而复杂的相互作用。然而，特异性5-HT受体激动剂对传统DA相关行为的影响尚不清楚。我们在这些研究中的目标是表征5-HT受体激动剂对自发活动和垂直饲养措施的影响。SSRIs、氟西汀和西酞普兰在最高剂量下使自发活动和垂直直立显著降低，女性对西酞普兰显著更敏感。5-HT 1A激动剂8-OH-DPAT和5-HT 2C激动剂MK 212显著降低雄性和雌性小鼠的活动，雌性对8-OH-DPAT更敏感。相比之下，5-HT 1B激动剂RU 24969和5-HT 2A激动剂DOI都增加了活性，DOI表现出性别差异效应。最后，5-HT 3激动剂SR 57227仅在最低剂量的雌性小鼠中产生显著的运动增加。这些实验的结果定义了几种5-HT激动剂在雄性和雌性C57 BL/6 J小鼠中的运动概况，为进一步探索5-HT受体对活性的影响提供了基础。
It is well established that the dopamine (DA) and serotonin (5-HT) systems have extensive and complex interactions. However, the effects of specific 5-HT receptor agonists on traditionally DA-related behaviors remain unclear. Our goal in these studies was to characterize the effects of 5-HT receptor agonists on measures of locomotor activity and vertical rearing. The SSRIs fluoxetine and citalopram produced significant decreases in locomotor activity and vertical rearing at the highest doses used with females significant more sensitive to citalopram. The 5-HT1A agonist 8-OH-DPAT and the 5-HT2C agonist MK 212 significantly decreased activity in both male and female mice, with females more sensitive to 8-OH-DPAT. In contrast, the 5-HT1B agonist RU 24969 and the 5-HT2A agonist DOI both increased activity, with DOI exhibiting differential effects with regard to sex. Finally, the 5-HT3 agonist SR 57227 produced significant locomotor increases only in female mice at the lowest dose. The results of these experiments define locomotor profiles of several 5-HT agonists in male and female C57BL/6J mice, providing a foundation for further explorations of 5-HT receptor effects on activity.
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影响因子：
5
作者：
COSTALL, B;ENIOJUKAN, JF;NAYLOR, RJ
通讯作者：
NAYLOR, RJ
DOI：
10.1016/s0378-4347(97)00470-2
发表时间：
1997-12-19
期刊：
JOURNAL OF CHROMATOGRAPHY B
影响因子：
--
作者：
Holladay, JW;Dewey, MJ;Yoo, SD
通讯作者：
Yoo, SD
影响因子：
7.6
作者：
Berridge, Craig W.
通讯作者：
Berridge, Craig W.
影响因子：
4.7
作者：
Bubar, MJ;McMahon, LR;Cunningham, KA
通讯作者：
Cunningham, KA
影响因子：
3.4
作者：
BLANCHARD, DC;SHEPHERD, JK;BLANCHARD, RJ
通讯作者：
BLANCHARD, RJ