Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
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DOI：
10.1111/jcmm.16923
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发表时间：
2021-10
影响因子：
5.3
通讯作者：
Sun XL
中科院分区：
文献类型：
--
作者：
Li L;Cheng SQ;Guo W;Cai ZY;Sun YQ;Huang XX;Yang J;Ji J;Chen YY;Dong YF;Cheng H;Sun XL
冬凌草甲素是一种从中草药中提取的天然二萜类化合物，已被证明在各种疾病模型中发挥抗氧化应激作用。本研究的目的是研究冬凌草甲素对缺血性卒中中氧化应激诱导的内皮损伤的保护作用。我们发现冬凌草甲素修复血脑屏障（BBB）的完整性，表现为上调紧密连接蛋白（TJ蛋白）的表达，抑制外周炎性细胞的浸润和神经炎症，从而减少缺血性中风小鼠的梗死体积。此外，我们的研究结果表明，冬凌草甲素可以通过促进核因子-红细胞2相关因子2（Nrf-2）的核转位来保护氧化应激诱导的内皮损伤。其具体机制可能是AKT（Ser 473）/GSK 3 β（Ser 9）/Fyn信号通路的激活。本研究揭示了冬凌草甲素对缺血性脑卒中的治疗作用及其作用机制，为将中草药复方提取物开发成为缺血性脑卒中治疗的创新药物提供了基础依据。
Oridonin, a natural diterpenoid compound extracted from a Chinese herb, has been proved to exert anti‐oxidative stress effects in various disease models. The aim of the present study was to investigate the protective effects of oridonin on oxidative stress‐induced endothelial injury in ischaemic stroke. We found oridonin repaired blood‐brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby reduced infarct volume in ischaemic stroke mice. Furthermore, our results showed that oridonin could protect against oxidative stress‐induced endothelial injury via promoting nuclear translocation of nuclear factor‐erythroid 2 related factor 2 (Nrf‐2). The specific mechanism could be the activation of AKT(Ser473)/GSK3β(Ser9)/Fyn signalling pathway. Our findings revealed the therapeutic effect and mechanism of oridonin in ischaemic stroke, which provided fundamental evidence for developing the extracted compound of Chinese herbal medicine into an innovative drug for ischaemic stroke treatment.
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影响因子：
5.3
作者：
Okada T;Suzuki H;Travis ZD;Zhang JH
通讯作者：
Zhang JH
影响因子：
10.1
作者：
Cordes S;Mokhtari Z;Bartosova M;Mertlitz S;Riesner K;Shi Y;Mengwasser J;Kalupa M;McGeary A;Schleifenbaum J;Schrezenmeier J;Bullinger L;Diaz-Ricart M;Palomo M;Carrreras E;Beutel G;Schmitt CP;Beilhack A;Penack O
通讯作者：
Penack O
DOI：
10.1146/annurev-cellbio-100617-062608
发表时间：
2019-10-06
影响因子：
11.3
作者：
Langen UH;Ayloo S;Gu C
通讯作者：
Gu C
影响因子：
6.7
作者：
Jiang X;Andjelkovic AV;Zhu L;Yang T;Bennett MVL;Chen J;Keep RF;Shi Y
通讯作者：
Shi Y
影响因子：
8.3
作者：
Gauberti, Maxime;Lapergue, Bertrand;Gory, Benjamin
通讯作者：
Gory, Benjamin