Diversity of vaginal microbiota increases by the time of labor onset.
Diversity of vaginal microbiota increases by the time of labor onset.
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DOI：
10.1038/s41598-017-17972-0
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发表时间：
2017-12-14
影响因子：
4.6
通讯作者：
Rudi K
中科院分区：
文献类型：
--
作者：
Avershina E;Slangsvold S;Simpson MR;Storrø O;Johnsen R;Øien T;Rudi K
阴道微生物区系是新生儿细菌定植的重要早期来源。然而，只有几项小型研究调查了分娩期间阴道微生物区系的组成。在这项工作中，我们分析了在怀孕36周和分娩开始时收集的256名妇女的阴道拭子，这些妇女参与了一项关于益生菌补充剂预防子女特应性皮炎的随机安慰剂对照研究。尽管个体的阴道微生物群随着时间的推移是稳定的，但在分娩时采集的阴道拭子中，几个具有混合群落状态(CST)IV特征的细菌科的比例过高。从怀孕36周到出生，阿尔法多样性也有增加的趋势。在大多数女性中，CST在整个研究过程中保持不变。在将阴道微生物群从一种CST转移到另一种CST的女性中，大约一半转移到CST IV。尽管CST IV经常与细菌性阴道病有关，这反过来可能导致早产，但在我们的队列中，这种转变与自我报告的阴道病、早产或出生体重无关。益生菌消费没有改变阴道微生物区系。
Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed vaginal swabs collected at 36 weeks gestation and at the onset of labor from 256 women participating in a randomized placebo-controlled study of probiotic supplementation for the prevention of atopic dermatitis in offspring. Although individuals’ vaginal microbiota was stable over time, several bacterial families, which are characteristic of mixed community state type (CST) IV, were overrepresented in vaginal swabs sampled at labor. Alpha-diversity also tended to increase by between 36 weeks gestation and the onset of birth. In the majority of women, CST remained the same throughout the study. Among the women who switched their vaginal microbiota from one CST to another, approximately half shifted towards CST IV. Although CST IV is often associated with bacterial vaginosis, which in turn may lead to preterm birth, in our cohort this shift was not associated with self-reported vaginosis, preterm delivery or birthweight. Probiotic consumption did not alter vaginal microbiota.
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影响因子：
3.7
作者：
Laurence M;Hatzis C;Brash DE
通讯作者：
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影响因子：
15.5
作者：
Gottschick C;Deng ZL;Vital M;Masur C;Abels C;Pieper DH;Wagner-Döbler I
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Wagner-Döbler I
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作者：
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通讯作者：
Ravel J
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob