Associations of obesity, physical activity level, inflammation and cardiometabolic health with COVID-19 mortality: a prospective analysis of the UK Biobank cohort.
Associations of obesity, physical activity level, inflammation and cardiometabolic health with COVID-19 mortality: a prospective analysis of the UK Biobank cohort.
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DOI：
10.1136/bmjopen-2021-055003
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发表时间：
2021-11-03
期刊：
影响因子：
2.9
通讯作者：
Bishop N
中科院分区：
文献类型：
--
作者：
Hamrouni M;Roberts MJ;Thackray A;Stensel DJ;Bishop N
调查不同体重指数 (BMI) 类别中体力活动水平与 COVID-19 死亡风险的关联，并确定肥胖个体较高体力活动水平的保护性关联是否可以通过心脏代谢和炎症生物标志物的有利水平来解释。前瞻性队列研究（2006 年至 2010 年期间收集的基线数据）。使用国际体力活动问卷评估体力活动水平（高：≥3000 MET 代谢当量（MET）分钟/周，中度：≥600 MET-分钟/周，低：不符合任一标准），并对血液样本进行生化测定以提供生物标志物数据。英国生物银行。针对潜在混杂因素进行逻辑回归调整，以确定暴露变量与 COVID-19 死亡风险的关联。 COVID-19 的死亡率是通过与国家医疗服务 (NHS) 数字链接的死亡证明来确定的。在 259 397 名参与者中，2020 年 3 月 16 日至 2021 年 2 月 27 日期间发生了 397 例 COVID-19 死亡。与 BMI 正常的高活动个体（参考组）相比，高活动肥胖个体的 COVID-19 死亡率 OR（95% CI）为 1.61（0.98 至 2.64），2.85（1.78 至 4.57）对于低度活动的肥胖个体，该值是 1.94（1.04 至 3.61），对于低活动度且 BMI 正常的个体。在纳入的生物标志物中，中性粒细胞计数和单核细胞计数与 COVID-19 死亡风险显着正相关。在一项仅限于肥胖个体的子分析中，对这些生物标志物进行调整后，与高度活跃的肥胖个体相比，低活动度肥胖个体的 COVID-19 死亡风险降低了 10%。这项研究提供了新的证据，表明高体力活动水平可能会降低与肥胖相关的 COVID-19 死亡风险。尽管这种保护性关联可能部分是由中性粒细胞和单核细胞计数较低来解释的，但该分析中包含的生物标志物仍然很大程度上无法解释。
To investigate the associations of physical activity level with COVID-19 mortality risk across body mass index (BMI) categories, and to determine whether any protective association of a higher physical activity level in individuals with obesity may be explained by favourable levels of cardiometabolic and inflammatory biomarkers. Prospective cohort study (baseline data collected between 2006 and 2010). Physical activity level was assessed using the International Physical Activity Questionnaire (high: ≥3000 Metabolic Equivalent of Task (MET)-min/week, moderate: ≥600 MET-min/week, low: not meeting either criteria), and biochemical assays were conducted on blood samples to provide biomarker data. UK Biobank. Logistic regressions adjusted for potential confounders were performed to determine the associations of exposure variables with COVID-19 mortality risk. Mortality from COVID-19 was ascertained by death certificates through linkage with National Health Service (NHS) Digital. Within the 259 397 included participants, 397 COVID-19 deaths occurred between 16 March 2020 and 27 February 2021. Compared with highly active individuals with a normal BMI (reference group), the ORs (95% CIs) for COVID-19 mortality were 1.61 (0.98 to 2.64) for highly active individuals with obesity, 2.85 (1.78 to 4.57) for lowly active individuals with obesity and 1.94 (1.04 to 3.61) for lowly active individuals with a normal BMI. Of the included biomarkers, neutrophil count and monocyte count were significantly positively associated with COVID-19 mortality risk. In a subanalysis restricted to individuals with obesity, adjusting for these biomarkers attenuated the higher COVID-19 mortality risk in lowly versus highly active individuals with obesity by 10%. This study provides novel evidence suggesting that a high physical activity level may attenuate the COVID-19 mortality risk associated with obesity. Although the protective association may be partly explained by lower neutrophil and monocyte counts, it still remains largely unexplained by the biomarkers included in this analysis.
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影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
DOI：
10.4103/1947-2714.136901
发表时间：
2014-07
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Loprinzi P;Smit E;Lee H;Crespo C;Andersen R;Blair SN
通讯作者：
Blair SN
影响因子：
8.1
作者：
Hojyo S;Uchida M;Tanaka K;Hasebe R;Tanaka Y;Murakami M;Hirano T
通讯作者：
Hirano T
DOI：
10.1111/j.1600-0838.2006.00602.x
发表时间：
2007-10-01
影响因子：
4.1
作者：
Fischer, C. P.;Berntsen, A.;Pedersen, B. K.
通讯作者：
Pedersen, B. K.
DOI：
10.1097/00005768-199911001-00025
发表时间：
1999-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Blair, SN;Brodney, S
通讯作者：
Brodney, S