Corticofugal VIP Gabaergic Projection Neurons in the Mouse Auditory and Motor Cortex.
Corticofugal VIP Gabaergic Projection Neurons in the Mouse Auditory and Motor Cortex.
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小鼠听觉和运动皮层中的皮质曲果VIP GABA能投射神经元。
DOI：
10.3389/fncir.2021.714780
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发表时间：
2021
影响因子：
3.5
通讯作者：
Apicella AJ
中科院分区：
文献类型：
--
作者：
Bertero A;Garcia C;Apicella AJ
解剖学和生理学研究已经将皮质描述为六层结构，其接收、加工和发送信息专门作为兴奋性输出到皮质和皮质下区域。这一概念越来越受到一些解剖学和功能研究的挑战，这些研究表明，直接抑制性皮层输出也是感觉和运动皮层的共同特征。与它们的兴奋性对应物类似，生长抑素和小清蛋白表达神经元的子集已被证明支配远端靶点，如感觉和运动纹状体和对侧皮质。然而，没有证据表明长距离VIP表达神经元，GABA能皮层抑制性神经元的第三大类，已被证明在这样的皮层区域。在这里，使用解剖顺行和逆行病毒追踪，我们测试的假设，VIP表达的神经元的小鼠听觉和运动皮层也可以发送远程投影到皮层和皮层下区域。我们能够证明，第一次，VIP表达的听觉皮层的神经元不仅可以达到对侧听觉皮层和同侧纹状体和杏仁核，如生长抑素和Parvalbumin表达长程神经元，但也内侧膝状体和上级和下丘。我们还证明，VIP表达神经元的运动皮层发送远程GABA能投射到背侧纹状体和对侧皮质。由于它存在于两个不同的皮层区域，这表明长距离VIP投射可能是皮层网络的一般特征。
Anatomical and physiological studies have described the cortex as a six-layer structure that receives, elaborates, and sends out information exclusively as excitatory output to cortical and subcortical regions. This concept has increasingly been challenged by several anatomical and functional studies that showed that direct inhibitory cortical outputs are also a common feature of the sensory and motor cortices. Similar to their excitatory counterparts, subsets of Somatostatin- and Parvalbumin-expressing neurons have been shown to innervate distal targets like the sensory and motor striatum and the contralateral cortex. However, no evidence of long-range VIP-expressing neurons, the third major class of GABAergic cortical inhibitory neurons, has been shown in such cortical regions. Here, using anatomical anterograde and retrograde viral tracing, we tested the hypothesis that VIP-expressing neurons of the mouse auditory and motor cortices can also send long-range projections to cortical and subcortical areas. We were able to demonstrate, for the first time, that VIP-expressing neurons of the auditory cortex can reach not only the contralateral auditory cortex and the ipsilateral striatum and amygdala, as shown for Somatostatin- and Parvalbumin-expressing long-range neurons, but also the medial geniculate body and both superior and inferior colliculus. We also demonstrate that VIP-expressing neurons of the motor cortex send long-range GABAergic projections to the dorsal striatum and contralateral cortex. Because of its presence in two such disparate cortical areas, this would suggest that the long-range VIP projection is likely a general feature of the cortex’s network.
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影响因子：
7.7
作者：
Jager P;Moore G;Calpin P;Durmishi X;Salgarella I;Menage L;Kita Y;Wang Y;Kim DW;Blackshaw S;Schultz SR;Brickley S;Shimogori T;Delogu A
通讯作者：
Delogu A
影响因子：
16.2
作者：
Keller AJ;Dipoppa M;Roth MM;Caudill MS;Ingrosso A;Miller KD;Scanziani M
通讯作者：
Scanziani M
DOI：
10.1093/cercor/bhv202
发表时间：
2015-12
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Prönneke A;Scheuer B;Wagener RJ;Möck M;Witte M;Staiger JF
通讯作者：
Staiger JF
影响因子：
25
作者：
Lee, Soohyun;Kruglikov, Illya;Huang, Z. Josh;Fishell, Gord;Rudy, Bernardo
通讯作者：
Rudy, Bernardo
影响因子：
5.3
作者：
Bertero, Alice;Feyen, Paul Luc Caroline;Apicella, Alfonso Junior
通讯作者：
Apicella, Alfonso Junior