Developmental patterns of hair cortisol in male and female nonhuman primates: lower hair cortisol levels in vervet males emerge at puberty.
Developmental patterns of hair cortisol in male and female nonhuman primates: lower hair cortisol levels in vervet males emerge at puberty.
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DOI：
10.1016/j.psyneuen.2012.03.015
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发表时间：
2012-10
影响因子：
3.7
通讯作者：
Fairbanks, Lynn A.
中科院分区：
文献类型：
--
作者：
Laudenslager, Mark L.;Jorgensen, Matthew J.;Fairbanks, Lynn A.
关键词：
关于年龄和性别对下丘脑垂体肾上腺（HPA）活性短期标志物的影响，研究得出了不一致的结果。头发皮质醇提供了一个回顾性的替代措施的累积活动的HPA轴在过去的3-4个月期间。为了描述这种生物标志物的潜在发展趋势，我们在一项对350只黑尾长尾雉（222只雌性和128只雄性）的横断面研究中评估了1 -12岁之间的毛发皮质醇水平。根据年龄将猴分组为1岁（幼年）、2岁（幼年）、3岁（青春期早期）、4岁（成年晚期-幼年）和5-12岁（成年），以便将完全成熟的动物纳入5-12岁年龄组。我们观察到，毛发皮质醇水平在年轻猴子中较高，并随年龄增长而下降（p<0.001）。更重要的是，年龄的影响与性别显著相互作用（p= 0.02），从3岁开始，男性的头发皮质醇始终低于女性（p<0.05或更好）。女性的发育衰退比男性早一年开始，这表明在人类和非人类灵长类动物中典型的早期成熟过程的影响。男性皮质醇水平较低的优势可能与许多非人灵长类动物青春期男性移民的社会群体模式有关。
Studies have yielded inconsistent results with regard to effects of age and sex on short term markers of hypothalamic pituitary adrenal (HPA) activity. Hair cortisol provides a retrospective proxy measure of the cumulative activity of the HPA axis over the preceding 3-4 month period. In order to describe potential developmental trends in this biomarker, we assessed hair cortisol levels between1-12 years of age in a cross-sectional study of 350 vervets (222 females and 128 males). Monkeys were grouped according to age as 1 (young juvenile), 2 (juvenile), 3 (early adolescent), 4 (late adolescent-young adult), and 5-12 (adult) years of age such that fully mature animals were included in the 5-12 year old age group. We observed that hair cortisol level was higher among the younger monkeys and declined with age (p<.001). More importantly the effect of age significantly interacted with sex (p=.02), such that hair cortisol was consistently lower in males than females beginning at age 3 (p<.05 or better). The developmental decline began one year earlier in females than males suggesting an influence of the earlier maturational processes typical in both human and nonhuman primates. The advantage of lower cortisol levels in the males may be related to social group patterns of male emigration during adolescence in many nonhuman primate species.
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影响因子：
2.9
作者：
Laudenslager, Mark L.;Jorgensen, Matthew J.;Grzywa, Rachel;Fairbanks, Lynn A.
通讯作者：
Fairbanks, Lynn A.
影响因子：
7.6
作者：
Young, EA;Carlson, NE;Brown, MB
通讯作者：
Brown, MB
影响因子：
7.6
作者：
Rubinow, DR;Roca, CA;Nieman, L
通讯作者：
Nieman, L
影响因子：
3.7
作者：
Stroud, Laura R.;Papandonatos, George D.;Williamson, Douglas E.;Dahl, Ronald E.
通讯作者：
Dahl, Ronald E.
影响因子：
2.9
作者：
D'Anna-Hernandez, Kimberly L.;Ross, Randal G.;Laudenslager, Mark L.
通讯作者：
Laudenslager, Mark L.