Sex differences in cortisol response to corticotropin releasing hormone challenge over puberty: Pittsburgh Pediatric Neurobehavioral Studies.
Sex differences in cortisol response to corticotropin releasing hormone challenge over puberty: Pittsburgh Pediatric Neurobehavioral Studies.
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DOI：
10.1016/j.psyneuen.2011.02.017
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发表时间：
2011-09
影响因子：
3.7
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
--
作者：
Stroud, Laura R.;Papandonatos, George D.;Williamson, Douglas E.;Dahl, Ronald E.
下丘脑-垂体-肾上腺皮质（HPA）轴调节的一致性性别差异已在动物模型中显示，并在青春期出现。然而，在人类中的平行工作是缺乏的，尽管阐明青春期抑郁症的性别差异的出现的影响。我们在一个仔细筛选的正常样本中研究了青春期HPA对促肾上腺皮质激素释放激素（CRH）激发反应的性别差异。参与者是68名健康儿童（41%为女孩），年龄在6-16岁之间，没有精神疾病的个人或家族史。青春期成熟通过坦纳分期确定。适应24小时后，在输注基线前30-40分钟、1 μg/kg CRH输注和输注后恢复90-180分钟内采集9-10份血浆皮质醇样本。37名参与者完成了2+ CRH挑战，允许在所有分析中纳入横断面和纵向数据。用非线性混合模型方法研究了性别和青春期成熟对皮质醇对CRH刺激反应参数的影响。女孩在青春期CRH激发后皮质醇总输出量增加，而男孩在青春期皮质醇总输出量变化不大。女孩皮质醇分泌增加的原因是反应和恢复速度较慢，导致达到皮质醇峰值的时间延长，并在青春期延迟恢复到基线。女孩在青春期的基线皮质醇也有所增加，而男孩在青春期的基线皮质醇有所下降。结果显示，在垂体水平上，青春期成熟对HPA调节的影响存在微妙的规范性性别差异。这种规范性的转变可能会导致抑郁症高危女孩的压力反应失调，并可能代表青春期女孩抑郁症发病率升高的一种潜在机制。
Consistent sex differences in regulation of the hypothalamic pituitary adrenocortical (HPA) axis have been shown in animal models and emerge over puberty. However, parallel work in humans is lacking despite implications for elucidating the emergence of sex differences in depression over puberty. We investigated sex differences in HPA response to corticotropin releasing hormone (CRH) challenge over puberty in a carefully screened normative sample. Participants were 68 healthy children (41% girls), ages 6–16, with no personal or family history of psychiatric disorder. Pubertal maturation was determined by Tanner staging. Following 24 hours of adaptation, 9–10 plasma cortisol samples were collected over 30–40 minutes pre-infusion baseline, 1 μg/kg CRH infusion, and 90–180 minutes post-infusion recovery. Thirty-seven participants completed 2+ CRH challenges allowing inclusion of cross-sectional and longitudinal data in all analyses. The influence of gender and pubertal maturation on parameters of cortisol response to CRH challenge was investigated using nonlinear mixed model metholodogy. Girls showed increasing total cortisol output following CRH challenge over puberty, while boys showed little change in total cortisol output over puberty. Increased cortisol output in girls was explained by slower reactivity and recovery rates leading to prolonged time to reach peak cortisol and delayed return to baseline over puberty. Girls also showed increasing baseline cortisol over puberty, while boys showed declining baseline over puberty. Results reveal subtle normative sex differences in the influence of pubertal maturation on HPA regulation at the pituitary level. This normative shift may tip the balance towards stress response dysregulation in girls at high risk for depression, and may represent one potential mechanism underlying elevated rates of depression among pubescent girls.
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影响因子：
3.3
作者：
Conley, Colleen S.;Rudolph, Karen D.
通讯作者：
Rudolph, Karen D.
影响因子：
--
作者：
CRITCHLOW, V;BARSELA, M;LIPSCOMB, HS
通讯作者：
LIPSCOMB, HS
影响因子：
6.8
作者：
Elmlinger, Martin W.;Kuehnel, Werner;Ranke, Michael B.
通讯作者：
Ranke, Michael B.
影响因子：
10.5
作者：
CARROLL, BJ
通讯作者：
CARROLL, BJ
影响因子：
10.6
作者：
DAHL, RE;KAUFMAN, J;PUIGANTICH, J
通讯作者：
PUIGANTICH, J