The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis.

The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis.
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DOI:
10.1016/j.cois.2020.07.003
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发表时间:
2020-10
影响因子:
5.3
通讯作者:
Karpac J
Karpac J
中科院分区:
农林科学2区
文献类型:
--
作者:
Zhao X;Karpac J

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后生动物复杂器官系统的进化决定了能量稳态的维持需要在具有特殊功能的器官之间协调局部和系统的能量需求。胃肠道是对能量底物摄取、储存和使用的系统协调必不可少的器官之一,在复杂的身体计划中,该器官的空间组织(即与其他代谢器官的接近)是其器官串扰作用的基础。对各种节肢动物肠道的研究,特别是对昆虫肠道的研究,揭示了胃肠道在维持能量稳态中的进化和功能。本文简要回顾了来自成年黑腹果蝇(Drosophila melanogaster)昆虫肠道(特别是中肠)的研究和理论,以了解胃肠道如何、如何以及为什么在脂质(昆虫中最常见的储存能量的形式)的系统调节中发挥作用。
The evolution of complex organ systems in metazoans has dictated that the maintenance of energy homeostasis requires coordinating local and systemic energy demands between organs with specialized functions. The gastrointestinal tract is one of many organs that is indispensable for the systemic coordination of energy substrate uptake, storage, and usage, and the spatial organization of this organ (i.e. proximity to other metabolic organs) within a complex body plan underlies its role in organ crosstalk. Studies of various arthropod intestines, and in particular insects, have shed light on the evolution and function of the gastrointestinal tract in the maintenance of energy homeostasis. This brief review focuses on studies and theories derived from the insect intestine (particularly the midgut) of adult Drosophila melanogaster to inform on the how, what, and why of the gastrointestinal tract in the systemic regulation of lipids, the most common form of stored energy in insects.
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