The P1 visual-evoked potential, red light, and transdiagnostic psychiatric symptoms.
The P1 visual-evoked potential, red light, and transdiagnostic psychiatric symptoms.
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DOI：
10.1016/j.brainres.2018.03.002
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发表时间：
2018-05-15
期刊：
影响因子：
2.9
通讯作者：
Schmidt J
中科院分区：
文献类型：
--
作者：
Bedwell JS;Spencer CC;Chan CC;Butler PD;Sehatpour P;Schmidt J
P1视觉诱发电位振幅降低已在几种精神疾病中报道，包括精神分裂症谱系、双相情感障碍和抑郁症。此外，在精神分裂症频谱样本中发现，与其对手颜色绿色相比，红色背景的P1振幅变化存在差异。当前的研究检查了在使用广泛的转诊断样本时是否会复制早期研究中与这些P1异常相关的特定精神症状。最终样本包括135名参与者：26名双相情感障碍患者，25名精神分裂症谱系障碍患者，19名单相抑郁症患者，62名目前没有精神疾病，3名其他类别的疾病患者。低（8%）和高（64%）的对比度检查阵列的灰色，绿色，红色背景条件下，脑电图，而眼动仪监测视觉固定的刺激。整个样本（N = 135）的线性回归发现，临床医生评定和自我报告的妄想/神奇思维的严重程度更高，与低对比度灰色（中性）背景条件下P1振幅降低相关。此外，在整个样本中，与绿色背景相比，红色背景下自我报告的更高收缩情感与P1振幅（在对比条件下的平均值）的更大降低相关。所有的关系仍然具有统计学意义的诊断类协变后，这表明他们是相对transdiagnosis的性质。这些研究结果表明，早期视觉处理异常可能更直接地与特定的transdiagnosis症状，如妄想和收缩的影响，而不是具体的精神病诊断或广泛的症状因素量表。
A reduced P1 visual-evoked potential amplitude has been reported across several psychiatric disorders, including schizophrenia-spectrum, bipolar, and depressive disorders. In addition, a difference in P1 amplitude change to a red background compared to its opponent color, green, has been found in schizophrenia-spectrum samples. The current study examined whether specific psychiatric symptoms that related to these P1 abnormalities in earlier studies would be replicated when using a broad transdiagnostic sample. The final sample consisted of 135 participants: 26 with bipolar disorders, 25 with schizophrenia-spectrum disorders, 19 with unipolar depression, 62 with no current psychiatric disorder, and 3 with disorders in other categories. Low (8%) and high (64%) contrast check arrays were presented on gray, green, and red background conditions during electroencephalogram, while an eye tracker monitored visual fixation on the stimuli. Linear regressions across the entire sample (N = 135) found that greater severity of both clinician-rated and self-reported delusions/magical thinking correlated with a reduced P1 amplitude on the low contrast gray (neutral) background condition. In addition, across the entire sample, higher self-reported constricted affect was associated with a larger decrease in P1 amplitude (averaged across contrast conditions) to the red, compared to green, background. All relationships remained statistically significant after covarying for diagnostic class, suggesting that they are relatively transdiagnostic in nature. These findings indicate that early visual processing abnormalities may be more directly related to specific transdiagnostic symptoms such as delusions and constricted affect rather than specific psychiatric diagnoses or broad symptom factor scales.
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影响因子：
10.6
作者：
Butler PD;Silverstein SM;Dakin SC
通讯作者：
Dakin SC
DOI：
10.1176/appi.ajp.2015.14091200
发表时间：
2016-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
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通讯作者：
Tamminga CA
影响因子：
3.1
作者：
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通讯作者：
Green, Michael F.
影响因子：
2.4
作者：
Brodeur, Mathieu B.;Kiang, Michael;Christensen, Bruce K.
通讯作者：
Christensen, Bruce K.
影响因子：
3.8
作者：
Butler, Pamela D.;Abeles, Ilana Y.;Sehatpour, Pejman
通讯作者：
Sehatpour, Pejman