India ink incorporated multifunctional phase-transition nanodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy.
India ink incorporated multifunctional phase-transition nanodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy.
复制标题
India Ink 结合多功能相变纳米液滴用于光声/超声双模态成像和基于光声效应的肿瘤治疗
作者：
Jian J;Liu C;Gong Y;Su L;Zhang B;Wang Z;Wang D;Zhou Y;Xu F;Li P;Zheng Y;Song L;Zhou X
气核微泡的体内应用受到气体扩散、快速体内清除和血管渗透性差的限制。为了克服这些局限性，使用改进的三步乳液工艺，我们开发了一种第一种印度墨水，其包含光学可降解的相变全氟化碳纳米液滴（IND），不仅可以提供三种类型的对比机制-常规/热弹性光声，相变/非线性光声和超声成像对比，而且还可以提供光声效应介导的肿瘤治疗的新途径。在高于相对低的能量阈值的脉冲激光照射下，IND的液-气相转变已经在体外和体内得到证实，为光声和超声双模态成像提供了优异的对比度。随着激光能量的进一步增加，纳米液滴已经被证明能够在体内破坏癌细胞，这可能是由于光声效应诱导的冲击波从结合的印度墨水的碳颗粒产生。所展示的结果表明，所开发的多功能相变纳米液滴在许多治疗诊断生物医学应用中具有巨大的潜力，包括光声/超声双模态分子成像和靶向局部癌症治疗。
The in vivo applications of gas-core microbubbles have been limited by gas diffusion, rapid body clearance, and poor vascular permeability. To overcome these limitations, using a modified three-step emulsion process, we have developed a first-of-its-kind India ink incorporated optically-triggerable phase-transition perfluorocarbon nanodroplets (INDs) that can provide not only three types of contrast mechanisms—conventional/thermoelastic photoacoustic, phase-transition/nonlinear photoacoustic, and ultrasound imaging contrasts, but also a new avenue for photoacoustic effect mediated tumor therapy. Upon pulsed laser illumination above a relatively low energy threshold, liquid-gas phase transition of the INDs has been demonstrated both in vitro and in vivo, offering excellent contrasts for photoacoustic and ultrasound dual-modality imaging. With further increased laser energy, the nanodroplets have been shown to be capable of destructing cancer cells in vivo, presumably due to the photoacoustic effect induced shock-wave generation from the carbon particles of the incorporated India ink. The demonstrated results suggest that the developed multifunctional phase-transition nanodroplets have a great potential for many theranostic biomedical applications, including photoacoustic/ultrasound dual-modality molecular imaging and targeted, localized cancer therapy.
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影响因子：
3.8
作者：
Di Ninni, Paola;Martelli, Fabrizio;Zaccanti, Giovanni
通讯作者：
Zaccanti, Giovanni
影响因子：
3.3
作者：
GODA, F;LIU, KJ;SWARTZ, HM
通讯作者：
SWARTZ, HM
影响因子：
17.1
作者：
Hannah A;Luke G;Wilson K;Homan K;Emelianov S
通讯作者：
Emelianov S
影响因子：
3.8
作者：
Kaneda, Megan M.;Caruthers, Shelton;Lanza, Gregory M.;Wickline, Samuel A.
通讯作者：
Wickline, Samuel A.
癌症消融
影响因子：
19
作者：
Li, Zhiwei;Yin, Shengnan;Liu, Zhuang
通讯作者：
Liu, Zhuang