Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.
Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment.
复制标题
DOI：
10.1002/jbt.21439
复制
发表时间：
2013-02
影响因子：
3.6
通讯作者：
Stapleton, Heather M.
中科院分区：
文献类型：
--
作者：
Patisaul, Heather B.;Roberts, Simon C.;Mabrey, Natalie;McCaffrey, Katherine A.;Gear, Robin B.;Braun, Joe;Belcher, Scott M.;Stapleton, Heather M.
关键词：
Firemaster® 550（FM 550）是一种用于泡沫基产品的阻燃混合物，最近被确定为家庭灰尘中的常见污染物。其主要成分的化学结构表明，它们具有内分泌干扰活性，但在与环境相关的接触水平下，它们的生理效应尚不清楚。本探索性研究的目的是评价FM 550在妊娠期和哺乳期暴露于100或1000 μg/天的大鼠中的蓄积、代谢和内分泌干扰作用。FM 550组分在暴露的母鼠和后代的组织中积累，并诱导后代中与代谢综合征相关的表型标志。影响包括母体血清甲状腺素水平升高和肝脏羧酸酯酶活性降低，雌性青春期提前、体重增加、雄性心脏肥大和后代探索行为改变。这项研究的结果是第一个牵连FM 550作为一种内分泌干扰物和肥胖在环境相关水平。
Firemaster® 550 (FM 550), a fire-retardant mixture used in foam-based products, was recently identified as a common contaminant in household dust. The chemical structures of its principle components suggest they have endocrine disrupting activity, but nothing is known about their physiological effects at environmentally relevant exposure levels. The goal of this exploratory study was to evaluate accumulation, metabolism and endocrine disrupting effects of FM 550 in rats exposed to 100 or 1000 μg/day across gestation and lactation. FM 550 components accumulated in tissues of exposed dams and offspring and induced phenotypic hallmarks associated with metabolic syndrome in the offspring. Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring. Results of this study are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels.
登录
查看更多内容
影响因子：
4.8
作者：
OJEDA, SR;WHEATON, JE;MCCANN, SM
通讯作者：
MCCANN, SM
影响因子：
3.6
作者：
Hogg, S
通讯作者：
Hogg, S
溴化阻燃剂：值得关注吗？
影响因子：
10.4
作者：
Birnbaum LS;Staskal DF
通讯作者：
Staskal DF
影响因子：
3.5
作者：
Cox, Kimberly H.;Gatewood, Jessica D.;Howeth, Chelsea;Rissman, Emilie F.
通讯作者：
Rissman, Emilie F.
影响因子：
11.8
作者：
Davis, Elizabeth F.;Klosterhaus, Susan L.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.