Developmental increase in top-down and bottom-up processing in a phonological task: an effective connectivity, fMRI study.
Developmental increase in top-down and bottom-up processing in a phonological task: an effective connectivity, fMRI study.
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DOI：
10.1162/jocn.2009.21065
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发表时间：
2009-06
影响因子：
3.2
通讯作者：
Booth JR
中科院分区：
文献类型：
--
作者：
Bitan T;Cheon J;Lu D;Burman DD;Booth JR
我们研究了儿童在对视觉呈现的单词进行押韵判断时大脑区域之间相互作用的年龄相关变化。任务的难度被操纵，包括任务相关（语音）信息和任务无关（正字法）信息之间的冲突。冲突的条件包括尽管有不同的拼写模式但押韵的单词对（jazz-has），或者尽管有相似的拼写模式但不押韵的单词（pint-mint）。这些是对比与非冲突的对，有相似的正字法和音韵（一角石灰）或不同的正字法和音韵（新闻列表）。使用功能磁共振成像，我们研究了五个左半球的利益区域之间的有效连接：梭状回（FG），额下回（IFG），顶内沟（IPS），外侧颞叶皮层（LTC），内侧额回（MeFG）。观察到IFG和FG对LTC的影响呈负相关增加，但仅在相互冲突的条件下。这些结果反映了自下而上和自上而下的信息在LTC上的趋同发展。在年龄较大的儿童中，自上而下的控制过程可能会选择性地增强LTC对来自FG的自下而上信息的敏感性。这在需要选择性增强任务相关信息与任务无关信息的情况下尤其明显。总之，这些结果为语言加工中自上而下控制过程的发展增加提供了直接证据。自下而上加工的发展增加可能是次要的自上而下的过程的增强。
We examined age-related changes in the interactions among brain regions in children performing rhyming judgments on visually presented words. The difficulty of the task was manipulated by including a conflict between task-relevant (phonological) information and task-irrelevant (orthographic) information. The conflicting conditions included pairs of words that rhyme despite having different spelling patterns ( jazz–has), or words that do not rhyme despite having similar spelling patterns ( pint–mint). These were contrasted with nonconflicting pairs that have similar orthography and phonology (dime–lime) or different orthography and phonology ( press–list). Using fMRI, we examined effective connectivity among five left hemisphere regions of interest: fusiform gyrus (FG), inferior frontal gyrus (IFG), intraparietal sulcus (IPS), lateral temporal cortex (LTC), and medial frontal gyrus (MeFG). Age-related increases were observed in the influence of the IFG and FG on the LTC, but only in conflicting conditions. These results reflect a developmental increase in the convergence of bottom–up and top–down information on the LTC. In older children, top–down control process may selectively enhance the sensitivity of the LTC to bottom–up information from the FG. This may be evident especially in situations that require selective enhancement of task-relevant versus task-irrelevant information. Altogether these results provide a direct evidence for a developmental increase in top–down control processes in language processing. The developmental increase in bottom–up processing may be secondary to the enhancement of top–down processes.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
14.5
作者：
Aron, AR;Monsell, S;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
5.7
作者：
Bitan, Tali;Burman, Douglas D.;Booth, James R.
通讯作者：
Booth, James R.
影响因子：
4.8
作者：
Gaillard, WD;Sachs, BC;Grandin, CB
通讯作者：
Grandin, CB
影响因子：
5.7
作者：
Berl, MM;Vaidya, CJ;Gaillard, WD
通讯作者：
Gaillard, WD