Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders.
Unraveling the mechanisms responsible for the comorbidity between metabolic syndrome and mental health disorders.
复制标题
DOI：
10.1159/000355632
复制
发表时间：
2013
影响因子：
4.1
通讯作者：
Sullivan EL
中科院分区：
文献类型：
--
作者：
Nousen EK;Franco JG;Sullivan EL
代谢综合征和精神疾病的患病率增加和高共病率促使人们对潜在的促进机制进行调查。代谢综合征与精神健康障碍（包括精神分裂症、双相情感障碍、抑郁症、焦虑症、注意力缺陷/多动障碍和自闭症谱系障碍）之间存在双向关联。药物副作用和社会影响是环境因素的贡献，但有一些共同的潜在神经和生理机制解释了这两种疾病之间的高并发症。炎症是两种疾病共有的状态，并且它有助于神经调节系统的破坏，包括肾上腺素能、多巴胺能和神经肽Y系统，以及下丘脑-垂体-肾上腺轴的失调。孕妇的代谢综合征也会使发育中的胎儿大脑暴露于炎症因子中，从而使后代易患代谢综合征和心理健康障碍。由于这些疾病的共同性质，治疗应同时解决心理健康和代谢紊乱的问题。此外，需要制定干预措施，以阻止将疾病风险增加转移到下一代。
The increased prevalence and high comorbidity of metabolic syndrome and mental health disorders have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between metabolic syndrome and mental health disorders including schizophrenia, bipolar disorder, depression, anxiety, attention deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems, including the serotonergic, dopaminergic, and neuropeptide Y systems, as well as dysregulation of the hypothalamic-pituitary-adrenal axis. Metabolic syndrome in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to metabolic syndrome and mental health disorders. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions need to be developed that can interrupt the transfer of increased risk of the disorders to the next generation.
登录
查看更多内容
影响因子：
3.8
作者：
Beckers, Sigri;Peeters, Armand;Van Hul, Wim
通讯作者：
Van Hul, Wim
影响因子：
13.6
作者：
Aarts, S.;van den Akker, M.;van Boxtel, M. P. J.;Jolles, J.;Winkens, B.;Metsemakers, J. F. M.
通讯作者：
Metsemakers, J. F. M.
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
--
作者：
Bajaj, Sarita;Agarwal, Shalabh Kumar;Singh, Vineet K
通讯作者：
Singh, Vineet K
影响因子：
5
作者：
ANDREWS, N;HOGG, S;FILE, SE
通讯作者：
FILE, SE