Association between exposure to the Chinese famine during infancy and the risk of self-reported chronic lung diseases in adulthood: a cross-sectional study.
Association between exposure to the Chinese famine during infancy and the risk of self-reported chronic lung diseases in adulthood: a cross-sectional study.
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婴儿期经历中国饥荒与成年后自我报告的慢性肺病风险之间的关联：一项横断面研究
DOI：
10.1136/bmjopen-2016-015476
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发表时间：
2017-06-02
期刊：
影响因子：
2.9
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Wang Z;Zou Z;Yang Z;Dong Y;Ma J
目的探讨中国饥荒早期暴露与成年期慢性肺部疾病风险之间的关系。设计数据分析来自横截面调查。本研究纳入了中国健康与退休纵向研究（CHARLS）2011-2012年基线调查的4135名受试者，以分析产前和产后早期饥饿暴露与成年期慢性肺部疾病风险之间的关系。主要结果测量慢性肺部疾病的定义基于自我报告的信息。结果胎儿暴露组、婴幼儿暴露组、学龄前暴露组和非暴露组的慢性肺部疾病患病率分别为6.5%、7.9%、6.8%和6.1%。在严重影响地区，婴儿暴露组患慢性肺部疾病的风险显著高于非暴露组（OR 1.95，95%CI 1.10至3.44），即使在调整性别、吸烟和饮酒、家庭经济状况和父母的最高教育程度后（OR 2.57，95%CI 1.26至5.25）。此外，在按性别和饥荒严重程度分层后，我们发现，只有婴儿暴露于严重饥荒与男性成年人慢性肺部疾病的风险升高相关（OR 3.16，95%CI 1.17至8.51）。结论婴儿期严重饥饿暴露可能增加成年男性慢性肺部疾病的发病风险。
Objective To examine the association between early-life exposure to the Chinese famine and the risk of chronic lung diseases in adulthood. Design Data analysis from a cross-sectional survey. Setting and participants 4135 subjects were enrolled into the study from the China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 baseline survey to analyse the associations between prenatal and early postnatal famine exposure and the risk of chronic lung diseases in adulthood. Main outcome measures Chronic lung diseases were defined based on self-reported information. Results The prevalence of self-reported chronic lung diseases in fetus-exposed, infant-exposed, preschool-exposed, and non-exposed groups was 6.5%, 7.9%, 6.8%, and 6.1%, respectively. The risk of chronic lung diseases in the infant-exposed group was significantly higher (OR 1.95, 95% CI 1.10 to 3.44) than the non-exposed group in severely affected areas, even after adjusting for gender, smoking, and drinking, family economic status, and the highest educational attainment of the parents (OR 2.57, 95% CI 1.26 to 5.25). In addition, after stratification by gender and famine severity, we found that only infant exposure to the severe famine was associated with the elevated risk of chronic lung diseases among male adults (OR 3.16, 95% CI 1.17 to 8.51). Conclusions Severe famine exposure during the period of infancy might increase the risk of chronic lung diseases in male adults.
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