Alcohol consumption and viral load are synergistically associated with CIN1.
Alcohol consumption and viral load are synergistically associated with CIN1.
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DOI：
10.1371/journal.pone.0072142
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kim MK
中科院分区：
文献类型：
--
作者：
Min KJ;Lee JK;Lee S;Kim MK
我们调查了饮酒与宫颈上皮内瘤变（CIN）和宫颈癌风险之间的关系，并确定参与韩国HPV队列研究（KHPV）的高危HPV阳性妇女的人乳头瘤病毒（HPV）病毒载量是否改变了这些关系。在2006年3月至2009年12月KHPV招募的女性中（n = 1,243），我们分析了正常细胞学（n = 581）作为对照组，CIN1 (n = 299), CIN2/3 （n = 161）或宫颈癌（n = 202）。采用多项逻辑分析估计多变量校正优势比（OR）。在调整潜在混杂因素后，饮酒者与不饮酒者相比，CIN1的风险增加（OR = 2.18, 95% CI 1.22-3.89）。经常饮酒的受试者有较高的CIN1风险（p表示线性趋势<0.0001）。较高的乙醇消耗量与CIN1风险增加相关（线性趋势p = 0.0001）。我们还观察到HPV病毒载量和饮酒之间的协同效应：高HPV病毒载量（≥100 RLU/PC）的饮酒者与CIN1风险显著增加相关（OR = 19.1; 95% CI, 6.60-55.3，交互作用p<0.001）。饮酒与CIN2/3或宫颈癌之间没有关联。在高危HPV阳性女性中，HPV病毒载量和酒精与CIN1风险相关。这是首次证明酒精是CIN1的独立和联合危险因素。
We investigated the association between alcohol consumption and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer, and determined whether these associations were modified by human papillomavirus (HPV) viral load in high-risk HPV-positive women participating in the Korean HPV cohort study (KHPV). Among the women recruited in the KHPV (n = 1,243) from March 2006 to December 2009, we analyzed normal cytology (n = 581) as control group, CIN1 (n = 299), CIN2/3 (n = 161), or cervical cancer (n = 202). Multinomial logistic analysis was performed to estimate multivariate-adjusted odds ratios (OR). Alcohol drinkers had an increased risk of CIN1 (OR = 2.18, 95% CI 1.22–3.89) compared with non-drinkers after adjusting for potential confounders. Subjects with more frequent alcohol consumption had a higher risk of CIN1 (p for linear trend <0.0001). Higher ethanol consumption was associated with an increased risk of CIN1 (p for linear trend = 0.0001). We also observed a synergistic effect between HPV viral load and alcohol consumption: drinkers with a high HPV viral load (≥100 RLU/PC) were associated with a significantly increased risk of CIN1 (OR = 19.1; 95% CI, 6.60–55.3, interaction p<0.001). There were no associations between alcohol drinking and CIN2/3 or cervical cancer. HPV viral load and alcohol was associated with the risk of CIN1 among high-risk HPV-positive women. This is the first demonstration that alcohol is an independent and combined risk factor of CIN1.
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影响因子：
2.8
作者：
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通讯作者：
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作者：
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通讯作者：
Ordi, Jaume
DOI：
10.1111/j.1530-0277.2001.tb02242.x
发表时间：
2001-04-01
影响因子：
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作者：
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通讯作者：
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