GABA Modulates Frequency-Dependent Plasticity in Humans.
GABA Modulates Frequency-Dependent Plasticity in Humans.
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DOI：
10.1016/j.isci.2020.101657
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发表时间：
2020-11-20
期刊：
影响因子：
5.8
通讯作者：
Parkes LM
中科院分区：
文献类型：
--
作者：
Lea-Carnall CA;Williams SR;Sanaei-Nezhad F;Trujillo-Barreto NJ;Montemurro MA;El-Deredy W;Parkes LM
初级躯体感觉皮层的频率依赖性重组，以及知觉变化，在重复的感觉刺激后出现。在这里，我们研究GABA在这个过程中的作用。我们共同刺激两个指尖和测量GABA和Glx使用磁共振（MR）光谱在刺激的开始和结束。参与者在刺激前后进行知觉学习任务。有2个会议的刺激频率或以上的共振频率的初级躯体感觉皮层（23和39赫兹，分别）。知觉学习仅在上述共振刺激后发生，而GABA在此条件下减少。较低水平的早期GABA与更大的知觉学习有关。这一发现背后的一个可能机制是，皮层去抑制“揭开”了皮层内的横向连接，以适应感觉环境。这些结果为人类的频率依赖性抑制机制提供了证据，并提出了一种基于机制的方法来优化神经刺激频率。在重复感觉刺激的背景下，GABA的释放是频率依赖性的，高于躯体感觉皮层的共振频率的刺激会减少GABA感知学习与GABA的减少有关早期GABA的减少为可塑性和学习打开了一扇窗分子神经科学;系统神经科学;认知神经科学
Frequency-dependent reorganization of the primary somatosensory cortex, together with perceptual changes, arises following repetitive sensory stimulation. Here, we investigate the role of GABA in this process. We co-stimulated two finger tips and measured GABA and Glx using magnetic resonance (MR) spectroscopy at the beginning and end of the stimulation. Participants performed a perceptual learning task before and after stimulation. There were 2 sessions with stimulation frequency either at or above the resonance frequency of the primary somatosensory cortex (23 and 39 Hz, respectively). Perceptual learning occurred following above resonance stimulation only, while GABA reduced during this condition. Lower levels of early GABA were associated with greater perceptual learning. One possible mechanism underlying this finding is that cortical disinhibition “unmasks” lateral connections within the cortex to permit adaptation to the sensory environment. These results provide evidence in humans for a frequency-dependent inhibitory mechanism underlying learning and suggest a mechanism-based approach for optimizing neurostimulation frequency. In the context of repetitive sensory stimulation, GABA release is frequency dependent Stimulating above the resonance frequency of the somatosensory cortex reduces GABA Perceptual learning is associated with a reduction in GABA Early GABA reduction opens a window for plasticity and learning Molecular Neuroscience; Systems Neuroscience; Cognitive Neuroscience
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影响因子：
4.2
作者：
Blicher JU;Near J;Næss-Schmidt E;Stagg CJ;Johansen-Berg H;Nielsen JF;Østergaard L;Ho YC
通讯作者：
Ho YC
影响因子：
16.2
作者：
Buzsáki G;Logothetis N;Singer W
通讯作者：
Singer W
影响因子：
5.5
作者：
BLISS, TVP;GARDNERM.AR
通讯作者：
GARDNERM.AR
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T
影响因子：
2.9
作者：
Herrmann CS;Rach S;Neuling T;Strüber D
通讯作者：
Strüber D