Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.
Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.
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环境锰暴露的生物标志物及其与儿童神经发育的关联：系统评价和荟萃分析
DOI：
10.1186/s12940-020-00659-x
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发表时间：
2020-10-02
期刊：
影响因子：
--
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Liu W;Xin Y;Li Q;Shang Y;Ping Z;Min J;Cahill CM;Rogers JT;Wang F
背景虽然先前的研究表明环境中的锰暴露与儿童神经发育障碍之间存在相关性，但结果并不确定。目前还没有一致的环境锰暴露生物标志物。在这里，我们总结了关于生物标记物中的锰与儿童神经发育之间的关系的研究，并提出了一个可靠的生物标记物。方法我们在PubMed和Web of Science上搜索可能相关的文章，直到2019年12月31日发表的英文文章。我们还进行了Meta分析，以量化接触锰对智商(IQ)的影响以及不同指标中锰的相关性。结果在确定的1754条引用中，55项研究纳入了13,388名受试者。队列研究的证据发现，较高的锰暴露对神经发育有负面影响，正如各种指标所表明的那样，主要影响6岁以下 儿童的认知和运动技能。横断面研究结果显示，在6-18岁的 儿童中，头发(H-Mn)和饮用水(W-Mn)中的锰含量升高，而与血液(B-Mn)或牙齿(T-Mn)中的锰含量无关，与认知和行为表现较差有关。在这些横断面研究中，大多数文献报道氢-锰的平均值超过0.55 μg/g。关于氢-锰的荟萃分析表明，发锰增加10倍与全量表智商下降2.51点(95%可信区间，− 4.58，− 0.45)相关，而B-锰和W-锰的荟萃分析没有产生如此显著的影响。混合相关分析表明，H-Mn与W-Mn的相关性比B-Mn更一致。尽管初步的Meta分析发现，只有在相对较低的水锰浓度(大多数低于50 μg/L)下，较高的W-Mn与较好的表现智商有关，但关于锰的性别差异的结果并不一致。结论较高的锰暴露与儿童神经发育呈负相关。头发是6-18 岁儿童接触锰的最可靠指标。对这些文献的分析表明，暴露于锰的神经发育存在性别差异，尽管我们的研究尚未阐明这一方面的明确模式。
BackgroundAlthough prior studies showed a correlation between environmental manganese (Mn) exposure and neurodevelopmental disorders in children, the results have been inconclusive. There has yet been no consistent biomarker of environmental Mn exposure. Here, we summarized studies that investigated associations between manganese in biomarkers and childhood neurodevelopment and suggest a reliable biomarker.MethodsWe searched PubMed and Web of Science for potentially relevant articles published until December 31th 2019 in English. We also conducted a meta-analysis to quantify the effects of manganese exposure on Intelligence Quotient (IQ) and the correlations of manganese in different indicators.ResultsOf 1754 citations identified, 55 studies with 13,388 subjects were included. Evidence from cohort studies found that higher manganese exposure had a negative effect on neurodevelopment, mostly influencing cognitive and motor skills in children under 6 years of age, as indicated by various metrics. Results from cross-sectional studies revealed that elevated Mn in hair (H-Mn) and drinking water (W-Mn), but not blood (B-Mn) or teeth (T-Mn), were associated with poorer cognitive and behavioral performance in children aged 6–18 years old. Of these cross-sectional studies, most papers reported that the mean of H-Mn was more than 0.55 μg/g. The meta-analysis concerning H-Mn suggested that a 10-fold increase in hair manganese was associated with a decrease of 2.51 points (95% confidence interval (CI), − 4.58, − 0.45) in Full Scale IQ, while the meta-analysis of B-Mn and W-Mn generated no such significant effects. The pooled correlation analysis revealed that H-Mn showed a more consistent correlation with W-Mn than B-Mn. Results regarding sex differences of manganese associations were inconsistent, although the preliminary meta-analysis found that higher W-Mn was associated with better Performance IQ only in boys, at a relatively low water manganese concentrations (most below 50 μg/L).ConclusionsHigher manganese exposure is adversely associated with childhood neurodevelopment. Hair is the most reliable indicator of manganese exposure for children at 6–18 years of age. Analysis of the publications demonstrated sex differences in neurodevelopment upon manganese exposure, although a clear pattern has not yet been elucidated for this facet of our study.
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影响因子：
3.4
作者：
de Water E;Proal E;Wang V;Medina SM;Schnaas L;Téllez-Rojo MM;Wright RO;Tang CY;Horton MK
通讯作者：
Horton MK
DOI：
10.1186/s12940-016-0174-4
发表时间：
2016-08-30
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Coetzee DJ;McGovern PM;Rao R;Harnack LJ;Georgieff MK;Stepanov I
通讯作者：
Stepanov I
影响因子：
8.3
作者：
Chiu YM;Claus Henn B;Hsu HL;Pendo MP;Coull BA;Austin C;Cagna G;Fedrighi C;Placidi D;Smith DR;Wright RO;Lucchini RG;Arora M
通讯作者：
Arora M
影响因子：
3.4
作者：
de Carvalho, Chrissie Ferreira;Oulhote, Youssef;Abreu, Neander
通讯作者：
Abreu, Neander
影响因子：
3.4
作者：
Bouchard, Maryse F.;Surette, Celine;Foucher, Delphine
通讯作者：
Foucher, Delphine