Silver nanoparticles as potential antiviral agents.
Silver nanoparticles as potential antiviral agents.
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DOI：
10.3390/molecules16108894
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发表时间：
2011-10-24
期刊：
影响因子：
--
通讯作者：
Galdiero M
中科院分区：
文献类型：
--
作者：
Galdiero S;Falanga A;Vitiello M;Cantisani M;Marra V;Galdiero M
病毒感染对全球健康构成重大挑战，特别是考虑到耐药病毒株的出现以及与长期使用相关的不良副作用继续减缓有效抗病毒疗法的应用。这使得迫切需要开发安全和有效的替代传统抗病毒药物。在目前的情况下，纳米材料已成为新型抗病毒剂，其独特的化学和物理性质提供的可能性。银纳米颗粒主要被研究用于其抗细菌的抗微生物潜力，但也被证明对几种类型的病毒具有活性，包括人免疫缺陷病毒、肝炎B病毒、单纯疱疹病毒、呼吸道合胞病毒和猴痘病毒。金属纳米颗粒的使用为新型抗病毒疗法提供了一个有趣的机会。由于金属可以攻击病毒中广泛的靶点，因此与常规抗病毒药物相比，产生耐药性的可能性较低。本文综述了银纳米粒子的制备方法及其作为抗病毒药物的应用。
Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, nanoscale materials have emerged as novel antiviral agents for the possibilities offered by their unique chemical and physical properties. Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses including human imunodeficiency virus, hepatitis B virus, herpes simplex virus, respiratory syncytial virus, and monkey pox virus. The use of metal nanoparticles provides an interesting opportunity for novel antiviral therapies. Since metals may attack a broad range of targets in the virus there is a lower possibility to develop resistance as compared to conventional antivirals. The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.
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