Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology.
Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology.
复制标题
路易体病理患者阿尔茨海默病病理学临床相关性的性别差异。
DOI：
10.1002/mds.29044
复制
发表时间：
2022-07
影响因子：
8.6
通讯作者：
Litvan, Irene
中科院分区：
文献类型：
--
作者：
Bayram, Ece;Coughlin, David G.;Litvan, Irene
路易体痴呆的临床诊断准确性有限，因为频繁的共病导致了临床的异质性。尽管在临床患病率和单纯淋巴细胞性病变的发生率上存在性别差异，但临床病理相关性的差异却鲜为人知。来自国家阿尔茨海默病协调中心的223名女性和468名男性患有边缘或新皮质脑白质脑白质脑病，根据病理将其分为两组，即大脑皮层脑白质脑病临床表型的高可能性和低/中可能性。分析了性别、性别与病理的交互作用与临床表型的关系。阿尔茨海默病的共同病理越严重，认知功能下降越严重，发生LB病临床表型的可能性越低。与男性相比，伴有严重AD共同病理和tau的女性认知功能减退更严重，发生AD临床表型的可能性更高。与女性相比，伴有更严重的AD共同病理的男性出现LB临床表型的可能性更低。性别和病理的相互作用在70岁到80岁之间的人中更加明显。AD共同病理降低了女性和男性发生LB临床表型的可能性，然而，男性可能有更高的诊断不足风险，女性可能有更高的痴呆症风险。使用LB和AD生物标记物，即使在LB或AD病理不是临床预期的情况下，对于准确诊断LB病和AD也是必要的。
Lewy body (LB) dementias have limited clinical diagnostic accuracy due to frequent co-pathologies contributing to clinical heterogeneity. Although sex differences in clinical prevalence and frequency of pure LB pathology were shown, differences for clinicopathological correlations are less known. Determining sex differences for clinical associations of Alzheimer’s disease (AD) co-pathology in those with LB pathology Data was from National Alzheimer’s Coordinating Center for 223 women and 468 men with limbic or neocortical LB, separated into two groups as those with high likelihood and low/intermediate likelihood for LB clinical phenotype based on pathology. Clinical associations of sex and interaction of sex and pathology for the clinical phenotype were analyzed. More severe AD co-pathology was associated with worse cognitive decline and lower likelihood of LB disease clinical phenotype. Women with more severe AD co-pathology and tau had worse cognitive decline and higher likelihood of AD clinical phenotype than men. Men with more severe AD co-pathology had lower likelihood of LB clinical phenotype than women. Interaction of sex and pathology was more pronounced in those aged between 70 and 80. AD co-pathology lowers the likelihood of LB clinical phenotype for both women and men, however, men may be at higher risk of LB disease underdiagnosis and women at higher risk of dementia. The use of both LB and AD biomarkers, even when LB or AD pathology is not clinically expected, is necessary for the accurate clinical diagnosis of both LB diseases and AD.
登录
查看更多内容
影响因子：
4.2
作者：
Coughlin DG;Phillips JS;Roll E;Peterson C;Lobrovich R;Rascovsky K;Ungrady M;Wolk DA;Das S;Weintraub D;Lee EB;Trojanowski JQ;Shaw LM;Vaishnavi S;Siderowf A;Nasrallah IM;Irwin DJ;McMillan CT;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
2.1
作者：
Besser L;Kukull W;Knopman DS;Chui H;Galasko D;Weintraub S;Jicha G;Carlsson C;Burns J;Quinn J;Sweet RA;Rascovsky K;Teylan M;Beekly D;Thomas G;Bollenbeck M;Monsell S;Mock C;Zhou XH;Thomas N;Robichaud E;Dean M;Hubbard J;Jacka M;Schwabe-Fry K;Wu J;Phelps C;Morris JC;Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
通讯作者：
Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
影响因子：
29
作者：
Hanseeuw, Bernard J.;Betensky, Rebecca A.;Johnson, Keith
通讯作者：
Johnson, Keith
影响因子：
3.2
作者：
Besser, Lilah M.;Kukull, Walter A.;Nelson, Peter T.
通讯作者：
Nelson, Peter T.
DOI：
10.1002/alz.12411
发表时间：
2022-04
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Choudhury P;Graff-Radford J;Aakre JA;Wurtz L;Knopman DS;Graff-Radford NR;Kantarci K;Forsberg LK;Fields JA;Pedraza O;Chen Q;Miyagawa T;Day GS;Tipton P;Savica R;Botha H;Lachner C;Dredla B;Reichard RR;Petersen RC;Dickson DW;Boeve BF;Ferman TJ
通讯作者：
Ferman TJ