Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk.
Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk.
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DOI：
10.1007/s10911-020-09452-5
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发表时间：
2020-06
影响因子：
2.5
通讯作者：
Arendt LM
中科院分区：
文献类型：
--
作者：
Hillers-Ziemer LE;Arendt LM
肥胖是绝经后乳腺癌的一个可预防的危险因素。无论绝经状态如何，患乳腺癌的肥胖妇女预后更差。乳腺组织由乳腺上皮细胞组成，组织成导管和小叶，并被富含脂肪的结缔组织包围。利用多种体内肥胖模型以及人类乳腺组织的研究有助于我们理解肥胖如何改变乳腺组织。乳腺上皮细胞群的局部变化、脂肪因子和血管生成介质的分泌升高、乳腺脂肪组织内的炎症和细胞外基质的重塑可能导致有利于乳腺癌生长的环境。尽管乳腺组织内的肥胖引起了这些显著的变化，但研究表明，一些但不是所有的肥胖引起的变化可能会随着体重减轻而减轻。在这里，我们回顾了我们目前对肥胖对乳腺微环境的影响的理解，肥胖引起的变化如何有助于乳腺肿瘤的进展，以及体重减轻对乳腺微环境的影响。
Obesity is a preventable risk factor for breast cancer following menopause. Regardless of menopausal status, obese women who develop breast cancer have a worsened prognosis. Breast tissue is comprised of mammary epithelial cells organized into ducts and lobules and surrounded by adipose-rich connective tissue. Studies utilizing multiple in vivo models of obesity as well as human breast tissue have contributed to our understanding of how obesity alters mammary tissue. Localized changes in mammary epithelial cell populations, elevated secretion of adipokines and angiogenic mediators, inflammation within mammary adipose tissue, and remodeling of the extracellular matrix may result in an environment conducive to breast cancer growth. Despite these significant alterations caused by obesity within breast tissue, studies have suggested that some, but not all, obesity-induced changes may be mitigated with weight loss. Here, we review our current understanding regarding the impact of obesity on the breast microenvironment, how obesity-induced changes may contribute to breast tumor progression, and the impact of weight loss on the breast microenvironment.
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影响因子：
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作者：
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