Exercise effects on depression: Possible neural mechanisms.
Exercise effects on depression: Possible neural mechanisms.
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DOI：
10.1016/j.genhosppsych.2017.04.012
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发表时间：
2017-11
影响因子：
7
通讯作者：
Erickson KI
中科院分区：
文献类型：
--
作者：
Gujral S;Aizenstein H;Reynolds CF 3rd;Butters MA;Erickson KI
抑郁症是一种压力和情绪调节失调的综合征，涉及额叶-边缘网络的结构完整性受损。荟萃分析证据表明，抑郁症成人常可观察到海马体、前扣带回、前额叶、纹状体和杏仁体的体积减少，以及白质完整性受损。运动已被证明是一种治疗抑郁症的有效方法，但很少有研究试图描述或确定这些影响的神经机制。在这篇综述中，我们研究了抑郁症患者的大脑结构异常与运动对大脑结构的影响之间的重叠，以强调可能介导运动对抑郁症状的积极影响的神经机制。前额叶皮质、前扣带回皮质、海马体和胼胝体作为结构性神经标记物出现，可能成为运动治疗抑郁症的靶标。这些发现强调了随机运动干预的必要性，以测试这些提出的运动治疗抑郁症的神经生物学机制。
Depression is a syndrome of stress- and emotion-dysregulation, involving compromised structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric reductions in the hippocampus, anterior cingulate cortex, prefrontal cortex, striatum, and amygdala, as well as compromised white matter integrity are frequently observed in depressed adults. Exercise has shown promise as an effective treatment for depression, but few studies have attempted to characterize or identify the neural mechanisms of these effects. In this review, we examined the overlap between structural brain abnormalities in depression and the effects of exercise on brain structure in adults, to highlight possible neural mechanisms that may mediate the positive effects of exercise on depressive symptoms. The prefrontal cortex, anterior cingulate cortex, hippocampus, and corpus callosum emerged as structural neural markers that may serve as targets for exercise-based treatments for depression. These findings highlight the need for randomized exercise interventions to test these proposed neurobiological mechanisms of exercise on depression.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
4.2
作者：
Erickson KI;Leckie RL;Weinstein AM
通讯作者：
Weinstein AM
DOI：
10.1016/j.pnpbp.2011.09.014
发表时间：
2012-01-10
影响因子：
5.6
作者：
Du, Ming-Ying;Wu, Qi-Zhu;Gong, Qi-Yong
通讯作者：
Gong, Qi-Yong
影响因子：
4.3
作者：
Du, Mingying;Liu, Jia;Gong, Qiyong
通讯作者：
Gong, Qiyong
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.