Enabling systems biology approaches through microfabricated systems.

Enabling systems biology approaches through microfabricated systems.
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DOI:
10.1021/ac401472y
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发表时间:
2013-10-01
影响因子:
7.4
通讯作者:
Lu, Hang
Lu, Hang
中科院分区:
化学1区
文献类型:
--
作者:
Zhan, Mei;Chingozha, Loice;Lu, Hang

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有了从还原论生物学的悠久历史中积累的实验工具和知识,我们现在可以开始把这些碎片放在一起,开始理解生物系统作为一个完整的整体是如何运作的。在这里,我们描述了微制造工具如何在解决吞吐量,分辨率和灵敏度的实验挑战,以支持基于系统的方法来生物学理解方面表现出了希望。
With the experimental tools and knowledge that have accrued from a long history of reductionist biology, we can now start to put the pieces together and begin to understand how biological systems function as an integrated whole. Here, we describe how microfabricated tools have demonstrated promise in addressing experimental challenges in throughput, resolution and sensitivity to support systems-based approaches to biological understanding.
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