Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults.
Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults.
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DOI：
10.1016/j.neuroimage.2020.117199
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发表时间：
2020-11-01
期刊：
影响因子：
5.7
通讯作者：
Rodrigue KM
中科院分区：
文献类型：
--
作者：
Webb CE;Foster CM;Horn MM;Kennedy KM;Rodrigue KM
阿尔茨海默病病理的最早指标之一是存在β-淀粉样蛋白(Aβ)沉积。显著的淀粉样蛋白沉积即使在没有或很少表现出明显的认知或记忆损害的老年人中也是明显的。帮助区分高度相似的记忆表征的基于海马体的过程可能是最容易受到早期疾病病理影响的。淀粉样蛋白与记忆的关系一直很难建立，可能是因为典型的记忆评估不会给海马体的操作带来足够的负担。因此，本研究使用了空间助记辨别任务，旨在对认知正常的中老年人(53-98岁)进行正电子发射计算机断层扫描(18F-β)的海马区模式分离/完成过程进行评估。学习的信息和新的信息之间的干扰程度不同，允许检查助记识别作为助记相似性的函数。结果表明，β-淀粉样蛋白负荷越大，对干扰水平降低的辨别力越差，这表明，即使认知正常的成年人中β-淀粉样蛋白的轻微升高，也与在要求海马体的记忆任务中表现不佳有关。目前的研究表明，淀粉样蛋白负荷的程度对老年人准确区分新旧信息的能力产生了负面影响，为β-淀粉样蛋白神经病理的认知表达提供了新的见解。
One of the earliest indicators of Alzheimer’s disease pathology is the presence of beta-amyloid (Aβ) protein deposition. Significant amyloid deposition is evident even in older adults who exhibit little or no overt cognitive or memory impairment. Hippocampal-based processes that help distinguish between highly similar memory representations may be the most susceptible to early disease pathology. Amyloid associations with memory have been difficult to establish, possibly because typical memory assessments do not tax hippocampal operations sufficiently. Thus, the present study utilized a spatial mnemonic discrimination task designed to tax hippocampal pattern separation/completion processes in a sample of cognitively normal middle-aged and older adults (53–98 years old) who underwent PET 18F-Florbetapir Aβ scanning. The degree of interference between studied and new information varied, allowing for an examination of mnemonic discrimination as a function of mnemonic similarity. Results indicated that greater beta-amyloid burden was associated with poorer discrimination across decreasing levels of interference, suggesting that even subtle elevation of beta-amyloid in cognitively normal adults is associated with impoverished performance on a hippocampally demanding memory task. The present study demonstrates that degree of amyloid burden negatively impacts the ability of aging adults to accurately distinguish old from increasingly distinct new information, providing novel insight into the cognitive expression of beta-amyloid neuropathology
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