Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity.
Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity.
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中国 2 型糖尿病患者的胰岛素抵抗与 C 反应蛋白相关，与腹部肥胖无关
DOI：
10.1186/1475-2840-9-92
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发表时间：
2010-12-19
影响因子：
9.3
通讯作者：
Hu R
中科院分区：
文献类型：
--
作者：
Lu B;Yang Y;Yang Z;Feng X;Wang X;Zhang Z;Hu R
关于c反应蛋白（CRP）和胰岛素抵抗之间的关系是否独立于身体肥胖，特别是中心性肥胖，存在争议。因此，我们分析了中国2型糖尿病患者CRP、胰岛素抵抗和肥胖之间的关系。方法本研究纳入520例诊断为2型糖尿病且CRP水平不超过10 mg/L的中国患者。胰岛素抵抗程度通过胰岛素抵抗稳态模型评估（HOMA-IR）来确定。CRP水平从最低浓度到最高浓度分为四分位数（Q1-Q4）。结果Q4、Q3、Q2的体重指数（BMI）和腰围（WC）均高于Q1。Q2、Q3和Q4的HOMA-IR高于Q1 （Q1 vs Q4, P < 0.001; Q1 vs Q3, P < 0.001; Q1 vs Q2, P = 0.028）。经Spearman相关分析，Log CRP与Log HOMA-IR（相关系数：0.230,P < 0.001）、BMI（相关系数：0.305,P < 0.001）、WC（相关系数：0.240,P < 0.001）呈显著相关。多元线性回归分析调整了年龄、性别和代谢综合征成分，log CRP也与log HOMA-IR （β系数，0.168,P < 0.001）和WC （β系数，0.131,P = 0.006）独立相关。结论中国2型糖尿病患者胰岛素抵抗与CRP水平相关，与腹部肥胖无关，提示腹部肥胖只能部分解释亚临床炎症与胰岛素抵抗之间的联系。
BackgroundThere is debate as to whether the association between C-reactive protein (CRP) and insulin resistance is independent of body fatness, particularly central obesity. Therefore, the association among CRP, insulin resistance and obesity was analyzed in Chinese patients with type 2 diabetes.MethodsThe study included 520 Chinese patients diagnosed with type 2 diabetes with CRP levels not exceeding 10 mg/L. The degree of insulin resistance was determined with the homeostasis model assessment of insulin resistance (HOMA-IR). The CRP levels were categorized into quartiles from the lowest to the highest concentrations (Q1-Q4).ResultsBody mass index (BMI) and waist circumference (WC) were both higher in Q4, Q3 and Q2 than those in Q1. HOMA-IR was higher in Q2, Q3 and Q4 than that in Q1 (Q1 vs Q4, P < 0.001; Q1 vs Q3, P < 0.001; Q1 vs Q2, P = 0.028). Log CRP was significantly correlated with log HOMA-IR (correlation coefficient: 0.230, P < 0.001) and BMI (correlation coefficient: 0.305, P < 0.001) and WC (correlation coefficient: 0.240, P < 0.001) by Spearman correlation analysis. Multiple linear regression analysis adjusting for age, gender and components of metabolic syndrome, log CRP was also independently associated with log HOMA-IR (β coefficient, 0.168; P < 0.001) and WC (β coefficient, 0.131; P = 0.006).ConclusionThese findings showed that insulin resistance was associated with CRP levels independent of abdominal obesity in Chinese patients with type 2 diabetes, suggesting that abdominal obesity could only partly explain the link between subclinical inflammation and insulin resistance.
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影响因子：
8.7
作者：
Hak, AE;Stehouwer, CDA;Witteman, JCM
通讯作者：
Witteman, JCM
DOI：
10.1186/1476-9255-7-36
发表时间：
2010-07-26
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Gupta AK;Johnson WD
通讯作者：
Johnson WD
DOI：
10.1001/jama.2010.1505
发表时间：
2010-10-27
期刊：
JAMA
影响因子：
--
作者：
Goodpaster BH;Delany JP;Otto AD;Kuller L;Vockley J;South-Paul JE;Thomas SB;Brown J;McTigue K;Hames KC;Lang W;Jakicic JM
通讯作者：
Jakicic JM
影响因子：
9.8
作者：
Lu, Bin;Yang, Yehong;Hu, Renming
通讯作者：
Hu, Renming
影响因子：
9.3
作者：
Miyazaki Y;DeFronzo RA
通讯作者：
DeFronzo RA