Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE).
Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE).
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DOI：
10.1371/journal.pone.0022112
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Sharma AM
中科院分区：
文献类型：
--
作者：
Anand SS;Tarnopolsky MA;Rashid S;Schulze KM;Desai D;Mente A;Rao S;Yusuf S;Gerstein HC;Sharma AM
我们试图确定南亚人和白种人之间脂肪组织的分布和特征的差异是否可以解释心血管疾病危险因素的差异。我们招募了 108 名健康的南亚人（36.8 岁）和白种人（34.2 岁），属于三个 BMI 阶层。评估身体成分、脂肪细胞大小、腹部脂肪面积和肝脏肥胖，并将其与空腹血糖、胰岛素、血脂和脂联素相关联。调整年龄、性别和 BMI 后，与白种人相比，南亚人的空腹胰岛素水平较高（平均差 (md)：0.44；95% CI：0.20–0.69），HDL 胆固醇较低（md：-0.13；95% CI：-0.26 至 -0.01），脂联素较低（md：-2.38；95% CI： −3.59 至 −1.17)。南亚人的体脂肪也较多（md：2.69；95% CI：0.70至4.69），瘦肌肉质量较低（md：-3.25；95% CI：-5.35至-1.14），腰臀比增加（md：0.03；95% CI：0.01-0.05），腹部皮下浅层脂肪组织较少（md： -2.94；95% CI：-5.56 至 -0.32），深层/内脏与浅表脂肪组织比率更高（md 0.34；95% CI：0.02 至 0.65），以及更多肝脏脂肪（md：7.43%；95% CI：2.30 至 12.55%）。与白种人相比，南亚人的脂肪细胞面积有所增加（md：64.26；95% CI：24.3 至 104.1）单位2。脂肪细胞面积的调整减弱了胰岛素（md：0.22；95％CI：-0.07至0.51）、HDL（md：-0.01；95％CI：-0.16至0.13）和脂联素（md：-1.11；95％CI：-2.61至0.39）的种族差异。对脂肪细胞面积和脂肪分布差异的调整减弱了肝脏脂肪的种族差异（md：5.19；95％CI：0.31至10.06）。与白人相比，南亚人的脂肪细胞面积更大。这种差异解释了胰岛素、高密度脂蛋白胆固醇、脂联素和肝脏异位脂肪沉积的种族差异。
We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease. We recruited 108 healthy South Asians (36.8 years) and white Caucasians (34.2 years) within three BMI strata. Body composition, adipocyte size, abdominal fat area, and hepatic adiposity were assessed and related to fasting glucose, insulin, lipids and adiponectin. After adjustment for age, sex, and BMI, South Asians compared to white Caucasians had higher ln fasting insulin (mean difference (md): 0.44; 95% CI: 0.20–0.69), lower HDL cholesterol (md: −0.13; 95% CI:−0.26 to −0.01), and lower adiponectin (md: −2.38; 95% CI: −3.59 to −1.17). South Asians also had more body fat (md: 2.69; 95% CI: 0.70 to 4.69), lower lean muscle mass (md: −3.25; 95%CI: −5.35 to −1.14), increased waist to hip ratio (md: 0.03; 95% CI: 0.01–0.05), less superficial subcutaneous abdominal adipose tissue (md: −2.94; 95% CI: −5.56 to−0.32), more deep/visceral to superficial adipose tissue ratio (md 0.34; 95% CI: 0.02 to 0.65), and more liver fat (md: 7.43%; 95% CI: 2.30 to 12.55%). Adipocyte area was increased in South Asians compared to white Caucasians (md: 64.26; 95% CI: 24.3 to 104.1) units2. Adjustment for adipocyte area attenuated the ethnic differences in insulin (md: 0.22; 95% CI: −0.07 to 0.51), HDL (md: −0.01; 95% CI: −0.16 to 0.13) and adiponectin (md: −1.11; 95% CI: −2.61 to 0.39). Adjustment for differences in adipocyte area and fat distribution attenuated the ethnic difference in liver fat (md: 5.19; 95% CI: 0.31 to 10.06). South Asians have an increased adipocyte area compared to white Caucasians. This difference accounts for the ethnic differences in insulin, HDL cholesterol, adiponectin, and ectopic fat deposition in the liver.
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影响因子：
16.2
作者：
Larson-Meyer, D. Enette;Heilbronn, Leonie K.;Ravussin, Eric
通讯作者：
Ravussin, Eric
影响因子：
16.2
作者：
Martin, Marlene;Palaniappan, Latha P.;Reaven, Peter D.
通讯作者：
Reaven, Peter D.
影响因子：
1.8
作者：
Owecki, M.;Miczke, A.;Sowifiski, J.
通讯作者：
Sowifiski, J.
影响因子：
5.9
作者：
Bays, Harold E.
通讯作者：
Bays, Harold E.
影响因子：
5.8
作者：
Hojbjerre, Lise;Rosenzweig, Mary;Stallknecht, Bente
通讯作者：
Stallknecht, Bente