Characteristic Assessment of Angiographies at Different Depths with AS-OCTA: Implication for Functions of Post-Trabeculectomy Filtering Bleb.
Characteristic Assessment of Angiographies at Different Depths with AS-OCTA: Implication for Functions of Post-Trabeculectomy Filtering Bleb.
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AS-OCTA 不同深度血管造影的特征评估：对小梁切除术后滤过泡功能的影响
DOI：
10.3390/jcm11061661
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发表时间：
2022-03-16
影响因子：
3.9
通讯作者：
Zhuo Y
中科院分区：
文献类型：
--
作者：
Luo M;Zhu Y;Xiao H;Huang J;Ling J;Huang H;Li Y;Zhuo Y
本研究旨在利用眼前节光学相干断层扫描血管造影（AS-OCTA）分析不同深度滤过泡功能的定量血管生物标志物。该横断面研究在Clinicaltrails.gov上注册（NCT 04515017）。46眼原发性开角型青光眼，行小梁切除术，丝裂霉素C超过6个月。测量滤过泡浅层（SL）、Tenon层（TL）和深层（DL）的血管密度（VD）和血管直径指数（RI）。失败组的VD和VD更高（均为p = 0.000）。在成功组中，SL、TL、DL的眼压和IOP之间存在显著相关性（分别为p = 0.013、0.016、0.031）。失败组中TL和DL的VD与IOP相关（p = 0.012，0.009）。Tenon's VD（TVD）和Tenon's眼压（TVD）与根据TVD、TVD和印第安纳州水泡外观分级量表（IBAGS）（p = 0.009，0.043）或Kenfeld分级系统（KGS）（p = 0.011，0.016）调整的IOP相关。预测手术失败的TVD、TVD、IBAGS和KGS的曲线下面积（AUC）分别为0.960、0.925、0.770和0.850。AS-OCTA实现了对血管，尤其是结膜下不可见血管的定量评价。AS-OCTA检测的TVD和TVD比传统分级系统更能反映滤过泡功能。
This study aimed to analyze the quantitative vascular biomarkers of filtering bleb function at different depths using anterior segment optical coherence tomography angiography (AS-OCTA). This cross-sectional study is registered on Clinicaltrails.gov (NCT 04515017). Forty-six eyes with primary open-angle glaucoma that had undergone trabeculectomy with mitomycin-C for more than six months were included. Vessel density (VD) and vessel diameter index (VDI) in the superficial layer (SL), Tenon’s layer (TL), and deep layer (DL) of the bleb were obtained. The VD and VDI were higher in the failure group (both p = 0.000). Significant correlations were found between the SL, TL, DL’s VDI, and IOP in the success group (p = 0.013, 0.016, 0.031, respectively). The VD of the TL and DL were related to IOP in the failure group (p = 0.012, 0.009). Tenon’s VD (TVD) and Tenon’s VDI (TVDI) correlated with IOP adjusting for TVD, TVDI, and the Indiana Bleb Appearance Grading Scale (IBAGS) (p = 0.009, 0.043) or Kenfeld grading system (KGS) (p = 0.011, 0.016). The area under curve (AUC) of the TVD, TVDI, IBAGS, and KGS to predict surgery failure were 0.960, 0.925, 0.770, and 0.850. AS-OCTA realized the quantitative evaluation of vessels, especially the invisible vascularity beneath the conjunctiva. TVD and TVDI as detected by AS-OCTA better reflected bleb function than conventional grading systems.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
4.2
作者：
Akagi T;Uji A;Huang AS;Weinreb RN;Yamada T;Miyata M;Kameda T;Ikeda HO;Tsujikawa A
通讯作者：
Tsujikawa A
影响因子：
4
作者：
Alsagoff, Z;Chew, PTK;Aung, T
通讯作者：
Aung, T
影响因子：
3.5
作者：
Choi, Woo June;Pepple, Kathryn L.;Wang, Ruikang K.
通讯作者：
Wang, Ruikang K.