Beyond cue reactivity: blunted brain responses to pleasant stimuli predict long-term smoking abstinence.
Beyond cue reactivity: blunted brain responses to pleasant stimuli predict long-term smoking abstinence.
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DOI：
10.1111/j.1369-1600.2011.00372.x
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发表时间：
2012-11
影响因子：
3.4
通讯作者：
Cinciripini PM
中科院分区：
文献类型：
--
作者：
Versace F;Lam CY;Engelmann JM;Robinson JD;Minnix JA;Brown VL;Cinciripini PM
确定复发风险较高的成瘾者将提供实施个性化干预措施和提高戒烟成功率的机会。不幸的是，预测药物停止治疗的长期成功的能力仍然困扰着研究人员。我们测试了大脑对情绪和与吸烟有关的图片的反应是否可以预测戒烟的能力。有兴趣戒烟的吸烟者（n=180）参加了一项戒烟临床试验。在开始任何治疗之前，我们记录了由情绪（愉快和不愉快）、中性和情绪相关图像诱发的事件相关电位（ERP）。根据对实验刺激的晚正电位（LPP）的幅值，采用聚类分析将吸烟者分为两组。虽然两组都表现出增强的反应，与刺激相关的线索，一组（n=81）也表现出迟钝的大脑反应，本质上令人愉快的刺激。后一组的吸烟者在戒烟日期后10周，12周和24周戒烟的可能性显着降低。总之，使用事件相关电位（一种直接测量大脑活动的方法），我们发现，大脑对本质上令人愉快的刺激反应迟钝的吸烟者长期戒烟的比率较低。这种反应提供了一种新的生物标志物，用于识别复发风险较高的吸烟者，并用于测试旨在使大脑奖励系统对内在愉快刺激的反应正常化的新干预措施的有效性。
Identifying addicts with higher risk of relapse would provide the opportunity to implement individualized interventions and increase cessation success rates. Unfortunately, the ability to predict the long-term success of drug-cessation treatments continues to elude researchers. We tested whether brain responses to emotional and cigarette-related pictures were predictive of the ability to abstain from smoking. Smokers interested in quitting (n=180) participated in a smoking cessation clinical trial. Before the initiation of any treatment we recorded event-related potentials (ERPs) evoked by emotional (both pleasant and unpleasant), neutral, and cigarette-related images. Cluster analysis was used to assign smokers to two groups based on the amplitude of the late positive potential (LPP) to the experimental stimuli. While both groups showed enhanced responses to cigarette-related cues, one group (n=81) also showed blunted brain responses to intrinsically pleasant stimuli. Smokers in the latter group were significantly less likely to be abstinent at 10, 12, and 24 weeks after their quit date. In conclusion, using event-related potentials, a direct measure of brain activity, we found that smokers with blunted brain responses to intrinsically pleasant stimuli had lower rates of long-term smoking abstinence. This response offers a new biomarker for identifying smokers at higher risk of relapse and for testing the efficacy of new interventions aimed at normalizing brain reward systems’ responses to intrinsically pleasant stimuli.
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影响因子：
4.7
作者：
Gilbert, David G.;Sugai, Chihiro;Froeliger, Brett
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Bradley, Margaret M.
影响因子：
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作者：
Goldstein, R. Z.;Woicik, P. A.;Volkow, N. D.
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